| IED ID |
IndEnz0005000524 |
| Enzyme Type ID |
lipase000524 |
| Protein Name |
Neuroligin-1
|
| Gene Name |
nlg-1 C40C9.5 |
| Organism |
Caenorhabditis elegans |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Nematoda (roundworms)
Chromadorea
Rhabditida
Rhabditina
Rhabditomorpha
Rhabditoidea
Rhabditidae
Peloderinae
Caenorhabditis
Caenorhabditis elegans
|
| Enzyme Sequence |
MERIYLLLLLFLPRIRSYDVRSVTTSWGMVRGEVVSPEGDDLPPVAQYLGIPYGVAPTGQYRFNMAISAAKWTHMPKDARKVSPVCIQTDMPELSETKAFKHTSAQRFDFNHRLLPHLKKQSEDCLYMNIYVPERLEISRDNYLPVMVIVHGEEYGWGTGNAFNGTTLAAYGHIIVVTLNYRLGVFGFLGRCESSSCSGNSGISDLVSALTMLNVILPSFGGDSKSVTLAGWGSGASLVSLLMASPLTQPGRRLFRRAILLDGSALSPWAISQNPQQYFMQLAEELACAPKNRTSSFNDNVDTIVRCMQVHSSENITKAVLKIDVPTFLSGFAPIVDGQLIPNKPQVSFSTQYGSLFREIDLLVGISSNPSHHMISNEDLKVGISKEKRMRIFRSLVRNLYDFHREEILASIINEYTDWENPRDHPKSIRNGVLNALSDVLYTAPLIETLRSHSADEVRKEANTFMFAFAHETRSWSQEQPNSGIRGSLSGDIVPYIFGYPLAQGDSEERLYSGFNTDDKGISKVMMHYVSNFVKSGDPSKPNPMSKNFPMGDVFHSTAWPQFDQPNREAYLEITDRPRVKNYYRNAQVGFWNNFIPQLHKNGKETEPVGEEHHLLSDHFRKDSYFGKTRHFSSYANLPFPPPPMPPSPPPELTTKPKPSESPTTLQTTTESEKAAAGSFTGKALGGVIFIGCGFLIMNVCLLIAVRREWGKKRRNEKKFQLQYQTYNSNHGGGAEQYNSLNSPEPLLSASHKNSTSMRPAGISPTCPRHGRAALALQNSRGNSLTAAQAPTLEEIQV |
| Enzyme Length |
798 |
| Uniprot Accession Number |
Q9XTG1 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Probable neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins (By similarity). Plays a role in the clustering of the GABA(A) receptor unc-49 at postsynaptic sites in neuromuscular junctions (NMJs) via the interaction with madd-4 and neurexin nrx-1 and is thereby required for normal GABAergic synaptic transmission (PubMed:26028574, PubMed:26028575). {ECO:0000250|UniProtKB:Q99K10, ECO:0000269|PubMed:26028574, ECO:0000269|PubMed:26028575}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Alternative sequence (1); Chain (1); Compositional bias (3); Disulfide bond (2); Glycosylation (3); Mutagenesis (2); Region (2); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords |
Alternative splicing;Cell adhesion;Cell junction;Cell membrane;Disulfide bond;Glycoprotein;Membrane;Reference proteome;Signal;Synapse;Transmembrane;Transmembrane helix |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, synapse {ECO:0000269|PubMed:26028574, ECO:0000269|PubMed:26028575}. Note=Localizes specifically to GABAergic synapses. {ECO:0000269|PubMed:26028574, ECO:0000269|PubMed:26028575}. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..17; /evidence=ECO:0000255 |
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
10778742;
15338614;
17486083;
17850180;
18255029;
20010541;
20083577;
20439776;
20699478;
21177967;
21611156;
22068627;
22267497;
22560298;
22723984;
22859820;
23800452;
24100941;
24453991;
24884423;
25232106;
25487147;
25726726;
26575289;
28669545;
29950505;
30559302;
32928959;
6593563;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
89,018 |
| Kinetics |
|
| Metal Binding |
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| Rhea ID |
|
| Cross Reference Brenda |
|