| IED ID | IndEnz0005000539 |
| Enzyme Type ID | lipase000539 |
| Protein Name |
Esterase B1 EC 3.1.1.1 |
| Gene Name | B1 |
| Organism | Culex pipiens (House mosquito) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Nematocera Culicomorpha Culicoidea Culicidae (mosquitos) Culicinae Culicini Culex Culex Culex pipiens complex Culex pipiens (House mosquito) |
| Enzyme Sequence | MSLESLTVQTKYGPVRGKRNVSLLGQEYVSFQGIPYARAPEGELRFKAPVPPQKWTETLDCTQQCEPCYHFDRRLQKIVGCEDSLKINVFAKEINPSTPLPVMLYIYGGGFTEGTSGTELYGPDFLVQKDIVLVSFNYRIGALGFLCCQSEQDGVPGNAGLKDQNLAIRWVLENIAAFGGDPKRVTLAGHSAGAASVQYHLISDASKDLFQRRIVMSGSTYSSWSLTRQRNWVEKLAKAIGWDGQGGESGALRFLRRAKPEDIVAHQEKLLTDQDMQDDIFTPFGPTVEPYLTEQCIIPKAPFEMARTAWGDKIDIMIGGTSEEGLLLLQKIKLHPELLSHPHLFLGNVPPNLKISMEKRIEFAAKLKQRYYPDSIPSMENNLGYVHMMSDRVFWHGLHRTILARAARSRARTFVYRICLDSEFYNHYRIMMIDPKLRGTAHADELSYLFSNFTQQVPGKETFEYRGLQTLVDVFSAFVINGDPNCGMTAKGGVVFEPNAQTKPTFKCLNIANDGVAFVDYPDADRLDMWDAMYVNDELF |
| Enzyme Length | 540 |
| Uniprot Accession Number | P16854 |
| Absorption | |
| Active Site | ACT_SITE 191; /note=Acyl-ester intermediate; /evidence=ECO:0000255|PROSITE-ProRule:PRU10039; ACT_SITE 324; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 442; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=a carboxylic ester + H2O = a carboxylate + an alcohol + H(+); Xref=Rhea:RHEA:21164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:30879, ChEBI:CHEBI:33308; EC=3.1.1.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10039}; |
| DNA Binding | |
| EC Number | 3.1.1.1 |
| Enzyme Function | FUNCTION: Overproduction of nonspecific esterases is a common mechanism of resistance to organophosphate insecticides. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (1); Glycosylation (1); Signal peptide (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Serine esterase;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..? |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 60,807 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:21164 |
| Cross Reference Brenda |