| IED ID | IndEnz0005000540 |
| Enzyme Type ID | lipase000540 |
| Protein Name |
Carboxylesterase 5A EC 3.1.1.1 Carboxylesterase-like urinary excreted protein homolog Cauxin Fragment |
| Gene Name | CES5A CES7 |
| Organism | Ovis aries (Sheep) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Caprinae Ovis Ovis aries (Sheep) |
| Enzyme Sequence | EDCLYLNIYAPAHAETGSKLPVMVWFPGGAFETGSASIFDGSALASYENVLVVTIQYRLGIFGFFNTGDEHARGNWAFMDQVAALVWVQENIEFFGGDPRCVTIFGESAGAISVSSLILSPMTKGLFHKAIMASGVAIIPYLKASDYERNDDLQTIASICDCNASDSVALLQCLRAKSSEELLSISQKTKSFTRVVDGLFFPNELLDLLAQKLFHLVPSIIGVNNHECGFLLPMKEFPEILGGSNKSLALQLIHSVLHIPVQYSYLVADEYFHNKHSLLDIRNRFLDLLGDVFFVVPGLVTAQYHTDAGAPVYFYEFQHRPQCLKDRKPPFVKADHTDEIRFVFGGAFLKGNIVMFEEATEEEKALSRKMMRYWANFARTG |
| Enzyme Length | 381 |
| Uniprot Accession Number | Q3T930 |
| Absorption | |
| Active Site | ACT_SITE 108; /note=Acyl-ester intermediate; /evidence=ECO:0000255|PROSITE-ProRule:PRU10039; ACT_SITE 227; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 336; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=a carboxylic ester + H2O = a carboxylate + an alcohol + H(+); Xref=Rhea:RHEA:21164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:30879, ChEBI:CHEBI:33308; EC=3.1.1.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10039, ECO:0000269|PubMed:16251497}; |
| DNA Binding | |
| EC Number | 3.1.1.1 |
| Enzyme Function | FUNCTION: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (1); Glycosylation (2); Non-terminal residue (2) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Reference proteome;Secreted;Serine esterase |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | PTM: N-glycosylated. {ECO:0000269|PubMed:16251497}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 42,468 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:21164 |
| Cross Reference Brenda |