| IED ID |
IndEnz0005000569 |
| Enzyme Type ID |
lipase000569 |
| Protein Name |
Helix-loop-helix protein 11
|
| Gene Name |
hlh-11 F58A4.7 |
| Organism |
Caenorhabditis elegans |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Nematoda (roundworms)
Chromadorea
Rhabditida
Rhabditina
Rhabditomorpha
Rhabditoidea
Rhabditidae
Peloderinae
Caenorhabditis
Caenorhabditis elegans
|
| Enzyme Sequence |
MVRSDSAEEDQIIIDDGFDLTEEDEEMMSSGTGALPVTIADWNSVTNARMAPPSIMSAASAFDLTASGMQNSLRSVLPTSTIGHAPMLANRSLSQPAPLSPTSLDPDRRSRMRRQIANCNERRRMQSINAGFLALRALLPRKEGEKLSKAAILQQTADMVHQLLGHKGEDIPDGGEPKKLKLEEDHHDADHQAQIAHLQTILETERAARKALESQVIQLRELLQMTTTSSQASSPVTPRSNGSGGFTLPSSYASSALPTPLRESPERKPSFQDTTSTPLSLLTLNGSPTSSESLASQRIFHPPPTLPSLETTVIRPTPLPPISVEISSPSLSTPSPLTAAPIIFSTAVPTQSSILFQTAAAAVTSAMSTGNSTPVALPHHLQGHNSAFVSTQPSLTLSQSMQTIVEAIRHLEGSHFIPTSPPPTSQTSLVR |
| Enzyme Length |
431 |
| Uniprot Accession Number |
P34474 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Transcriptional regulator (PubMed:33078707). Component of a feedback loop involving atfs-1, atgl-1 and hlh-11 (PubMed:33078707). Binds to the promoter of the atgl-1 lipase to negatively regulate the expression of atgl-1, and thereby promoting fat oxidation in response to mitochondrial stress and mitochondrial respiration in the intestine (PubMed:33078707). In addition, functions with atfs-1 to maintain lifespan (PubMed:33078707). May have a role in fertility and in positively regulating body size (PubMed:19855932). {ECO:0000269|PubMed:19855932, ECO:0000269|PubMed:33078707}. |
| Temperature Dependency |
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| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Alternative sequence (3); Chain (1); Compositional bias (2); Domain (1); Mutagenesis (1); Region (2) |
| Keywords |
Alternative splicing;DNA-binding;Nucleus;Reference proteome;Transcription;Transcription regulation |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:33078707}. |
| Modified Residue |
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| Post Translational Modification |
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| Signal Peptide |
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| Structure 3D |
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| Cross Reference PDB |
- |
| Mapped Pubmed ID |
11381264;
11408582;
12011109;
12431374;
17164286;
18425118;
19343510;
21085631;
21177967;
22286215;
22347378;
22560298;
22901814;
23540702;
23791784;
23800452;
25487147;
33235199;
|
| Motif |
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| Gene Encoded By |
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| Mass |
46,108 |
| Kinetics |
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| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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