Detail Information for IndEnz0005000595
IED ID IndEnz0005000595
Enzyme Type ID lipase000595
Protein Name Inactive pancreatic lipase-related protein 1
PL-RP1
Gene Name Pnliprp1 Plrp1
Organism Rattus norvegicus (Rat)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat)
Enzyme Sequence MLTLWTVSLFLLGAAQGKEVCYDNLGCFSDAEPWAGTAIRPLKLLPWSPEKINTRFLLYTNENPTAFQTLQLSDPLTIGASNFQVARKTRFIIHGFIDKGEENWVVDMCKNMFQVEEVNCICVDWKKGSQTTYTQAANNVRVVGAQVAQMIDILVKNYSYSPSKVHLIGHSLGAHVAGEAGSRTPGLGRITGLDPVEANFEGTPEEVRLDPSDADFVDVIHTDAAPLIPFLGFGTNQMSGHLDFFPNGGQSMPGCKKNALSQIVDIDGIWSGTRDFVACNHLRSYKYYLESILNPDGFAAYPCASYKDFESNKCFPCPDQGCPQMGHYADKFAGKSGDEPQKFFLNTGEAKNFARWRYRVSLILSGRMVTGQVKVALFGSKGNTRQYDIFRGIIKPGATHSSEFDAKLDVGTIEKVKFLWNNQVINPSFPKVGAAKITVQKGEERTEYNFCSEETVREDTLLTLLPCETSDTV
Enzyme Length 473
Uniprot Accession Number P54316
Absorption
Active Site ACT_SITE 171; /note=Nucleophile; /evidence=ECO:0000250; ACT_SITE 194; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU10037; ACT_SITE 281; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU10037
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity (in vitro) (By similarity). {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Disulfide bond (6); Domain (1); Glycosylation (1); Metal binding (4); Signal peptide (1)
Keywords Calcium;Disulfide bond;Glycoprotein;Metal-binding;Reference proteome;Secreted;Signal
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..17; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 17010228; 8203536; 8967484;
Motif
Gene Encoded By
Mass 52,378
Kinetics
Metal Binding METAL 205; /note=Calcium; via carbonyl oxygen; /evidence=ECO:0000250; METAL 208; /note=Calcium; via carbonyl oxygen; /evidence=ECO:0000250; METAL 210; /note=Calcium; /evidence=ECO:0000250; METAL 213; /note=Calcium; /evidence=ECO:0000250
Rhea ID
Cross Reference Brenda 3.1.1.26;