Detail Information for IndEnz0005000601
IED ID IndEnz0005000601
Enzyme Type ID lipase000601
Protein Name Colipase
Gene Name CLPS
Organism Myocastor coypus (Coypu) (Nutria)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Hystricomorpha Myocastoridae Myocastor Myocastor coypus (Coypu) (Nutria)
Enzyme Sequence MEKVLALVLLTLAVAYAAPDPRGLIINLDNGELCLNSAQCKSQCCQHDSPLGLARCADKARENSGCSPQTIYGIYYLCPCERGLTCDGDKSIIGAITNTNYGICQDPQSKK
Enzyme Length 111
Uniprot Accession Number P42889
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. {ECO:0000250|UniProtKB:P04118}.; FUNCTION: Enterostatin has a biological activity as a satiety signal. {ECO:0000250|UniProtKB:P04118}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Disulfide bond (5); Propeptide (1); Signal peptide (1)
Keywords Digestion;Direct protein sequencing;Disulfide bond;Lipid degradation;Lipid metabolism;Secreted;Signal
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..17; /evidence=ECO:0000269|PubMed:7851384
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 11,899
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda