| IED ID | IndEnz0005000609 |
| Enzyme Type ID | lipase000609 |
| Protein Name |
N-acylneuraminate cytidylyltransferase EC 2.7.7.43 CMP-N-acetylneuraminic acid synthase CMP-NeuNAc synthase CMP-sialic acid synthase |
| Gene Name | neuA gbs1233 |
| Organism | Streptococcus agalactiae serotype III (strain NEM316) |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Firmicutes Bacilli Lactobacillales Streptococcaceae Streptococcus Streptococcus agalactiae Streptococcus agalactiae serogroup III Streptococcus agalactiae serotype III (strain NEM316) |
| Enzyme Sequence | MKPICIIPARSGSKGLPDKNMLFLAGKPMIFHTIDAAIESGMFDKKDIFVSTDSELYREICLERGISVVMRKPELSTDQATSYDMLKDFLSDYEDNQEFVLLQVTSPLRKSWHIKEAMEYYSSHDVDNVVSFSEVEKHPGLFTTLSDKGYAIDMVGADKGYRRQDLQPLYYPNGAIFISNKETYLREKSFFTSRTYAYQMAKEFSLDVDTRDDFIHVIGHLFFDYAIREKENKVFYKEGYSRLFNREASKIILGDSKTISISLENYHNYSQGGVTLATMLENLPNFLTANVTEAFVSIGVNDLITGYSVEEIFSNFQKLYSLLAENKIKMRFTTIAYTLFRETVNNADIEKINQWLTEFCYQNQIPLLDINRFLSKDGNLNYHLTSDGLHFTQEANDLLQSQYQLFVDEVKTL |
| Enzyme Length | 413 |
| Uniprot Accession Number | P0A4V0 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=an N-acylneuraminate + CTP = a CMP-N-acyl-beta-neuraminate + diphosphate; Xref=Rhea:RHEA:11344, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:60073, ChEBI:CHEBI:68671; EC=2.7.7.43; Evidence={ECO:0000269|PubMed:8830246}; |
| DNA Binding | |
| EC Number | 2.7.7.43 |
| Enzyme Function | FUNCTION: Catalyzes the formation of CMP-N-acetylneuraminic acid (CMP-NeuNAc), which is essential for the formation of the capsule. {ECO:0000269|PubMed:8830246}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Sequence conflict (2) |
| Keywords | Capsule biogenesis/degradation;Cytoplasm;Exopolysaccharide synthesis;Magnesium;Manganese;Nucleotidyltransferase;Transferase |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 47,670 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:11344 |
| Cross Reference Brenda |