Detail Information for IndEnz0005000609
IED ID IndEnz0005000609
Enzyme Type ID lipase000609
Protein Name N-acylneuraminate cytidylyltransferase
EC 2.7.7.43
CMP-N-acetylneuraminic acid synthase
CMP-NeuNAc synthase
CMP-sialic acid synthase
Gene Name neuA gbs1233
Organism Streptococcus agalactiae serotype III (strain NEM316)
Taxonomic Lineage cellular organisms Bacteria Terrabacteria group Firmicutes Bacilli Lactobacillales Streptococcaceae Streptococcus Streptococcus agalactiae Streptococcus agalactiae serogroup III Streptococcus agalactiae serotype III (strain NEM316)
Enzyme Sequence MKPICIIPARSGSKGLPDKNMLFLAGKPMIFHTIDAAIESGMFDKKDIFVSTDSELYREICLERGISVVMRKPELSTDQATSYDMLKDFLSDYEDNQEFVLLQVTSPLRKSWHIKEAMEYYSSHDVDNVVSFSEVEKHPGLFTTLSDKGYAIDMVGADKGYRRQDLQPLYYPNGAIFISNKETYLREKSFFTSRTYAYQMAKEFSLDVDTRDDFIHVIGHLFFDYAIREKENKVFYKEGYSRLFNREASKIILGDSKTISISLENYHNYSQGGVTLATMLENLPNFLTANVTEAFVSIGVNDLITGYSVEEIFSNFQKLYSLLAENKIKMRFTTIAYTLFRETVNNADIEKINQWLTEFCYQNQIPLLDINRFLSKDGNLNYHLTSDGLHFTQEANDLLQSQYQLFVDEVKTL
Enzyme Length 413
Uniprot Accession Number P0A4V0
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=an N-acylneuraminate + CTP = a CMP-N-acyl-beta-neuraminate + diphosphate; Xref=Rhea:RHEA:11344, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:60073, ChEBI:CHEBI:68671; EC=2.7.7.43; Evidence={ECO:0000269|PubMed:8830246};
DNA Binding
EC Number 2.7.7.43
Enzyme Function FUNCTION: Catalyzes the formation of CMP-N-acetylneuraminic acid (CMP-NeuNAc), which is essential for the formation of the capsule. {ECO:0000269|PubMed:8830246}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Sequence conflict (2)
Keywords Capsule biogenesis/degradation;Cytoplasm;Exopolysaccharide synthesis;Magnesium;Manganese;Nucleotidyltransferase;Transferase
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 47,670
Kinetics
Metal Binding
Rhea ID RHEA:11344
Cross Reference Brenda