Detail Information for IndEnz0005000615
IED ID IndEnz0005000615
Enzyme Type ID lipase000615
Protein Name Inactive pancreatic lipase-related protein 1
PL-RP1
Gene Name PNLIPRP1 PLRP1
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MLIFWTITLFLLGAAKGKEVCYEDLGCFSDTEPWGGTAIRPLKILPWSPEKIGTRFLLYTNENPNNFQILLLSDPSTIEASNFQMDRKTRFIIHGFIDKGDESWVTDMCKKLFEVEEVNCICVDWKKGSQATYTQAANNVRVVGAQVAQMLDILLTEYSYPPSKVHLIGHSLGAHVAGEAGSKTPGLSRITGLDPVEASFESTPEEVRLDPSDADFVDVIHTDAAPLIPFLGFGTNQQMGHLDFFPNGGESMPGCKKNALSQIVDLDGIWAGTRDFVACNHLRSYKYYLESILNPDGFAAYPCTSYKSFESDKCFPCPDQGCPQMGHYADKFAGRTSEEQQKFFLNTGEASNFARWRYGVSITLSGRTATGQIKVALFGNKGNTHQYSIFRGILKPGSTHSYEFDAKLDVGTIEKVKFLWNNNVINPTLPKVGATKITVQKGEEKTVYNFCSEDTVREDTLLTLTPC
Enzyme Length 467
Uniprot Accession Number P54315
Absorption
Active Site ACT_SITE 171; /note=Nucleophile; ACT_SITE 194; /note=Charge relay system; ACT_SITE 281; /note=Charge relay system
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity). {ECO:0000250, ECO:0000269|PubMed:19824014}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Alternative sequence (4); Beta strand (23); Chain (1); Disulfide bond (6); Domain (1); Helix (13); Metal binding (4); Natural variant (5); Signal peptide (1); Turn (5)
Keywords 3D-structure;Alternative splicing;Calcium;Disulfide bond;Metal-binding;Reference proteome;Secreted;Signal
Interact With P41181; Q8NFU1; P11912; Q9HA82; Q7Z7G2; P00387; Q15125; Q5JX71; O15552; Q8TB36; P48165; O95377; Q8TDT2; O15529; Q8TED1; Q7Z5P4; P48051; A8MZ59; Q8N386; Q8NI22; Q6FHY5; P15941-11; Q9Y375; O14524-2; O00623; Q86VR2; Q3KNW5; P54219-3; O95436-2; Q9NQQ7-3; Q9NP94; P30825; Q16623; Q9NUH8; Q96Q45-2; Q6ZT21; Q9Y320; P19075
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1379598, ECO:0000269|PubMed:19824014}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..17; /evidence=ECO:0000255
Structure 3D X-ray crystallography (1)
Cross Reference PDB 2PPL;
Mapped Pubmed ID 16385451; 21516116; 23918603;
Motif
Gene Encoded By
Mass 51,848
Kinetics
Metal Binding METAL 205; /note=Calcium; via carbonyl oxygen; METAL 208; /note=Calcium; via carbonyl oxygen; METAL 210; /note=Calcium; METAL 213; /note=Calcium
Rhea ID
Cross Reference Brenda 3.1.1.26;