Detail Information for IndEnz0005000642
IED ID IndEnz0005000642
Enzyme Type ID lipase000642
Protein Name Juvenile hormone esterase, isoform A
JH esterase
JHE-A
EC 3.1.1.59
Fragments
Gene Name
Organism Trichoplusia ni (Cabbage looper)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Amphiesmenoptera Lepidoptera (butterflies and moths) Glossata Neolepidoptera Heteroneura Ditrysia Obtectomera Noctuoidea Noctuidae (owlet moths) Plusiinae Trichoplusia Trichoplusia ni (Cabbage looper)
Enzyme Sequence LPSLSADAEAPSPLSLKADAPLAHIDSGLLGVPYAKQPIGELRVTTLRLIELPPEKLVVGAPVYLYQFSYESPSSAIKQEVVGHIEDLTYVFKGSQYQDIESPTAYQSK
Enzyme Length 109
Uniprot Accession Number P30809
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=H2O + juvenile hormone I = H(+) + juvenile hormone I carboxylate + methanol; Xref=Rhea:RHEA:46916, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17790, ChEBI:CHEBI:83641, ChEBI:CHEBI:87109; EC=3.1.1.59; Evidence={ECO:0000250|UniProtKB:P19985}; CATALYTIC ACTIVITY: Reaction=H2O + juvenile hormone III = H(+) + juvenile hormone III carboxylate + methanol; Xref=Rhea:RHEA:46912, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17790, ChEBI:CHEBI:27493, ChEBI:CHEBI:83274; EC=3.1.1.59; Evidence={ECO:0000250|UniProtKB:P19985};
DNA Binding
EC Number 3.1.1.59
Enzyme Function FUNCTION: JH esterase plays a crucial role in the decrease of JH activity in lepidopteran insects, by hydrolyzing the methyl ester of JH. It is also involved in the transport of JH. {ECO:0000250|UniProtKB:P19985}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Non-adjacent residues (6); Non-terminal residue (1)
Keywords Direct protein sequencing;Hydrolase;Reference proteome;Serine esterase
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 11,814
Kinetics
Metal Binding
Rhea ID RHEA:46916; RHEA:46912
Cross Reference Brenda