IED ID | IndEnz0005000650 |
Enzyme Type ID | lipase000650 |
Protein Name |
Acetylcholinesterase 1 AChE 1 EC 3.1.1.7 |
Gene Name | ace-1 CBG16374 |
Organism | Caenorhabditis briggsae |
Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis briggsae |
Enzyme Sequence | MRYSLLFFIFLPCVITAVDLIHLHDGSPLFGEEVLSQTGKPLTRFLGIPFAEPPIGNLRFRKPKPKQPWRIPFNATTPPNSCIQSEDTYFGDFYGSTMWNPNTKLSEDCLYLNVYVPGKVDPNKKLAVMIWVYGGGFWSGTSTLDVYDGRILTVEENVILVAMNYRVSIFGFLYMNRSEAPGNMGMWDQLLAMKWVHKNIDLFGGDTSRITLFGESAGAASVSIHMLSQKSAPYFHRAIIQSGSATSPWAIEPRDVALARAVILYNAMKCGNMSLISPDYDRILDCFQRADADALRENEWAPVREFGDFPWVPVVDGDFLLENAQTSLKQGNFKKTQLLAGSNRDESIYFLTYQLPDIFPVADFFSKSEFIKDRQTWIKGVKDLLPRQILKCQLTLAAVLHEYEPQDLPISAQNWLNAMDKMLGDYHFTCSVNEMALAHTKHGGDTFYYYFTHRATQQTWPEWMGVLHGYEINFIFGEPFNQKRFNYTDEERELSNRFMRYWANFAKTGDPNKNEDGSFTQDIWPKYNSVSMEYMNMTVESSYPGQNRIGHGPRRKECAFWKAYLPNLMAAVADVGDPYLVWKQQMDKWQNEYITDWQYHFEQYKRYQTYRQSDSETCGG |
Enzyme Length | 620 |
Uniprot Accession Number | Q27459 |
Absorption | |
Active Site | ACT_SITE 216; /note=Acyl-ester intermediate; /evidence=ECO:0000255|PROSITE-ProRule:PRU10039; ACT_SITE 346; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 468; /note=Charge relay system; /evidence=ECO:0000250 |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | CATALYTIC ACTIVITY: Reaction=acetylcholine + H2O = acetate + choline + H(+); Xref=Rhea:RHEA:17561, ChEBI:CHEBI:15354, ChEBI:CHEBI:15355, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089; EC=3.1.1.7; |
DNA Binding | |
EC Number | 3.1.1.7 |
Enzyme Function | FUNCTION: Rapidly hydrolyzes choline released into the synapse. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Active site (3); Chain (1); Disulfide bond (4); Glycosylation (4); Signal peptide (1) |
Keywords | Cell junction;Cell membrane;Disulfide bond;Glycoprotein;Hydrolase;Membrane;Neurotransmitter degradation;Reference proteome;Secreted;Serine esterase;Signal;Synapse |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Cell junction, synapse {ECO:0000250}. Secreted {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=May be secreted or membrane associated via a non-catalytic subunit. {ECO:0000250}. |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | SIGNAL 1..31; /evidence=ECO:0000255 |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | - |
Motif | |
Gene Encoded By | |
Mass | 71,501 |
Kinetics | |
Metal Binding | |
Rhea ID | RHEA:17561 |
Cross Reference Brenda |