Detail Information for IndEnz0005000661
IED ID IndEnz0005000661
Enzyme Type ID lipase000661
Protein Name Apolipoprotein C-II
Apo-CII
ApoC-II
Apolipoprotein C2

Cleaved into: Proapolipoprotein C-II
ProapoC-II
Gene Name APOC2
Organism Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Cercopithecoidea Cercopithecidae (Old World monkeys) Cercopithecinae Macaca (macaques) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Enzyme Sequence MGTRFLLALCLVLLVLGFEVQGAQLPQQDEPPSPALLSRVQESLSSYWESAKAAAQKLYEKTYLPAVDEKLRDLYSKSTAAMSTYTGIFTDQVLSVLKGEE
Enzyme Length 101
Uniprot Accession Number P18658
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. {ECO:0000250|UniProtKB:P02655}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (2); Region (2); Sequence conflict (2); Signal peptide (1)
Keywords Chylomicron;Direct protein sequencing;Glycoprotein;HDL;LDL;Lipid degradation;Lipid metabolism;Lipid transport;Reference proteome;Secreted;Sialic acid;Signal;Transport;VLDL
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02655}.
Modified Residue
Post Translational Modification PTM: Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing. {ECO:0000250|UniProtKB:P02655}.; PTM: Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma. {ECO:0000250|UniProtKB:P02655}.
Signal Peptide SIGNAL 1..22; /evidence=ECO:0000269|PubMed:3105581
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 11,145
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda