Detail Information for IndEnz0005000665
IED ID IndEnz0005000665
Enzyme Type ID lipase000665
Protein Name Apolipoprotein C-III
Apo-CIII
ApoC-III
Apolipoprotein C3
Gene Name APOC3
Organism Cavia porcellus (Guinea pig)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Hystricomorpha Caviidae (cavies) Cavia (guinea pigs) Cavia porcellus (Guinea pig)
Enzyme Sequence MQPRVLLAVTLLALLVSARAEEIQESSLLGVMKDYMQQASKTANEMLTKVQESQVAENAREWMTESLDSMKGYWTSLIGRLSGFLDSTPSS
Enzyme Length 91
Uniprot Accession Number Q9Z2R5
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners. {ECO:0000250|UniProtKB:P02656}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Modified residue (1); Region (1); Signal peptide (1); Site (1)
Keywords Chylomicron;Lipid degradation;Lipid metabolism;Lipid transport;Oxidation;Reference proteome;Secreted;Signal;Transport;VLDL
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02656}.
Modified Residue MOD_RES 63; /note=Methionine sulfoxide; /evidence=ECO:0000250|UniProtKB:P33622
Post Translational Modification
Signal Peptide SIGNAL 1..20; /evidence=ECO:0000250
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 10,099
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda