| IED ID |
IndEnz0005000695 |
| Enzyme Type ID |
lipase000695 |
| Protein Name |
Neuropeptide receptor 22
|
| Gene Name |
npr-22 Y59H11AL.1 |
| Organism |
Caenorhabditis elegans |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Nematoda (roundworms)
Chromadorea
Rhabditida
Rhabditina
Rhabditomorpha
Rhabditoidea
Rhabditidae
Peloderinae
Caenorhabditis
Caenorhabditis elegans
|
| Enzyme Sequence |
MDEGGGIGSSLLSRITTTASEIMMRNEPTTTENPAVQEMNHIYHLTPSMKMLCILFYSILCVCCVYGNVLVILVIVYFKRLRTATNILILNLAVADLLISVFCIPFSYWQVLIYDDQRWLFGSMMCSLLAFLQAMAVFLSAWTLVVISFDRWMAIMFLLTPNIRITRRRALYLVAATWIFSILMALPLLFTTRFFEDQDGLPNCGENWTYFGDSGEQVRKVYSSMVLILQYVVPQAVLIITYTHIGIKMWNSRVPGMQNGATKKMIVDRHESVKKLVPMVILISALFALCWLPLLILINVIPEFYPDINSWGYILYLWWFAHGLAMSHSMVNPIIYFIRNARFREGFCFFSSKLLPCISFKELRLLTDNTSRSFRNRSRFSGVINPTSSDEKPATSLTRYSRSGVLDRQTCRSARFFEARPLVVVRNNSANSLA |
| Enzyme Length |
434 |
| Uniprot Accession Number |
Q59E83 |
| Absorption |
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| Active Site |
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| Activity Regulation |
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| Binding Site |
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| Calcium Binding |
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| catalytic Activity |
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| DNA Binding |
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| EC Number |
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| Enzyme Function |
FUNCTION: Receptor for the LURY-1-1 and LURY-1-2 peptides which control food-related processes including feeding, lifespan, egg-laying and roaming behavior (PubMed:28847365). Receptor for flp-7 which stimulates serotonin-induced fat loss (PubMed:28128367). Serotonin induces secretion of flp-7 from neurons and binding to npr-22 which leads to induction of the atgp-1 lipase and subsequent fat loss (PubMed:28128367). Acts in vitro as a receptor for the flp-7 FMRFamide-like neuropeptides TPMQRSSMVRF-amide, SPMQRSSMVRF-amide, SPMERSAMVRF-amide and SPMDRSKMVRF-amide (PubMed:16377032). Also acts in vitro as a receptor for a number of other FMRFamide-like neuropeptides including the flp-1 neuropeptide PNFMRY-amide, the flp-9 neuropeptide KPSFVRF-amide, the flp-11 neuropeptides AMRNALVRF-amide, ASGGMRNALVRF-amide and NGAPQPFVRF-amide, the flp-13 neuropeptides AADGAPLIRF-amide, ASPSAPLIRF-amide, SPSAVPLIRF-amide, SAAAPLIRF-amide and ASSAPLIRF-amide, and the flp-22 neuropeptide SPSAKWMRF-amide (PubMed:16377032). The SPMERSAMVRF-amide neuropeptide from flp-7 acts as the strongest in vitro activator of npr-22 (PubMed:16377032). {ECO:0000269|PubMed:16377032, ECO:0000269|PubMed:28128367, ECO:0000269|PubMed:28847365}. |
| Temperature Dependency |
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| PH Dependency |
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| Pathway |
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| nucleotide Binding |
|
| Features |
Alternative sequence (1); Chain (1); Disulfide bond (1); Glycosylation (1); Topological domain (8); Transmembrane (7) |
| Keywords |
Alternative splicing;Cell membrane;Disulfide bond;G-protein coupled receptor;Glycoprotein;Membrane;Receptor;Reference proteome;Transducer;Transmembrane;Transmembrane helix |
| Interact With |
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| Induction |
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| Subcellular Location |
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. |
| Modified Residue |
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| Post Translational Modification |
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| Signal Peptide |
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| Structure 3D |
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| Cross Reference PDB |
- |
| Mapped Pubmed ID |
12097347;
17164286;
17417969;
18801967;
19343510;
20439776;
22286215;
22347378;
22560298;
22901814;
23800452;
25487147;
26949257;
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| Motif |
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| Gene Encoded By |
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| Mass |
49,751 |
| Kinetics |
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| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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