Detail Information for IndEnz0005000695
IED ID IndEnz0005000695
Enzyme Type ID lipase000695
Protein Name Neuropeptide receptor 22
Gene Name npr-22 Y59H11AL.1
Organism Caenorhabditis elegans
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans
Enzyme Sequence MDEGGGIGSSLLSRITTTASEIMMRNEPTTTENPAVQEMNHIYHLTPSMKMLCILFYSILCVCCVYGNVLVILVIVYFKRLRTATNILILNLAVADLLISVFCIPFSYWQVLIYDDQRWLFGSMMCSLLAFLQAMAVFLSAWTLVVISFDRWMAIMFLLTPNIRITRRRALYLVAATWIFSILMALPLLFTTRFFEDQDGLPNCGENWTYFGDSGEQVRKVYSSMVLILQYVVPQAVLIITYTHIGIKMWNSRVPGMQNGATKKMIVDRHESVKKLVPMVILISALFALCWLPLLILINVIPEFYPDINSWGYILYLWWFAHGLAMSHSMVNPIIYFIRNARFREGFCFFSSKLLPCISFKELRLLTDNTSRSFRNRSRFSGVINPTSSDEKPATSLTRYSRSGVLDRQTCRSARFFEARPLVVVRNNSANSLA
Enzyme Length 434
Uniprot Accession Number Q59E83
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Receptor for the LURY-1-1 and LURY-1-2 peptides which control food-related processes including feeding, lifespan, egg-laying and roaming behavior (PubMed:28847365). Receptor for flp-7 which stimulates serotonin-induced fat loss (PubMed:28128367). Serotonin induces secretion of flp-7 from neurons and binding to npr-22 which leads to induction of the atgp-1 lipase and subsequent fat loss (PubMed:28128367). Acts in vitro as a receptor for the flp-7 FMRFamide-like neuropeptides TPMQRSSMVRF-amide, SPMQRSSMVRF-amide, SPMERSAMVRF-amide and SPMDRSKMVRF-amide (PubMed:16377032). Also acts in vitro as a receptor for a number of other FMRFamide-like neuropeptides including the flp-1 neuropeptide PNFMRY-amide, the flp-9 neuropeptide KPSFVRF-amide, the flp-11 neuropeptides AMRNALVRF-amide, ASGGMRNALVRF-amide and NGAPQPFVRF-amide, the flp-13 neuropeptides AADGAPLIRF-amide, ASPSAPLIRF-amide, SPSAVPLIRF-amide, SAAAPLIRF-amide and ASSAPLIRF-amide, and the flp-22 neuropeptide SPSAKWMRF-amide (PubMed:16377032). The SPMERSAMVRF-amide neuropeptide from flp-7 acts as the strongest in vitro activator of npr-22 (PubMed:16377032). {ECO:0000269|PubMed:16377032, ECO:0000269|PubMed:28128367, ECO:0000269|PubMed:28847365}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Alternative sequence (1); Chain (1); Disulfide bond (1); Glycosylation (1); Topological domain (8); Transmembrane (7)
Keywords Alternative splicing;Cell membrane;Disulfide bond;G-protein coupled receptor;Glycoprotein;Membrane;Receptor;Reference proteome;Transducer;Transmembrane;Transmembrane helix
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 12097347; 17164286; 17417969; 18801967; 19343510; 20439776; 22286215; 22347378; 22560298; 22901814; 23800452; 25487147; 26949257;
Motif
Gene Encoded By
Mass 49,751
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda