| IED ID | IndEnz0005000700 |
| Enzyme Type ID | lipase000700 |
| Protein Name |
Tear acid lipase-like protein TALLP |
| Gene Name | |
| Organism | Mesocricetus auratus (Golden hamster) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Cricetidae Cricetinae (hamsters) Mesocricetus Mesocricetus auratus (Golden hamster) |
| Enzyme Sequence | MSWLLSTMCLVHVCGNIFCLFETTTNPEAYMKVSKIVNHWGYTSEEYEAVTEDGYILPLNRIPHGKNNINSTAPKKVVLCQHGLFSTAGVWVSNPPSNSLAFILADAGFDVWMGNSRGSTWAKKHLYLDPNSKEFWAFSFDEMIKYDLPATINFILKKTGQKQIYYIGHSQGALIALGAFSTNQKLAEKIKLCFLLAPIATLKHVEGIVSLLPYFYPTAFKVVFSEKEFLSAVAFSKLHGYSCNAKVINDGCVAIFLSMTGYVPQHLNKSRVDVYIRHSLAGTSVQTLLHYRQAIKKGVFEAYDWGSQSLNMLHYNQTTPPLYNVEDMKIPTAMWSGGKDSLADTKDVAHLVPKISNLIYHKITADFSHLDFTVGKNAYYVSNDILKLLDKSETENLH |
| Enzyme Length | 398 |
| Uniprot Accession Number | Q3YBN2 |
| Absorption | |
| Active Site | ACT_SITE 170; /note=Nucleophile; /evidence=ECO:0000250|UniProtKB:P07098; ACT_SITE 340; /note=Charge relay system; /evidence=ECO:0000250|UniProtKB:P07098; ACT_SITE 369; /note=Charge relay system; /evidence=ECO:0000250|UniProtKB:P07098 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Female-specific protein which lacks detectable lipase activity against a range of substrates. Binds the hydrophobic lipid 1-aminoanthracene with high affinity. {ECO:0000269|PubMed:17141562}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (1); Glycosylation (1); Sequence conflict (1); Signal peptide (1) |
| Keywords | Direct protein sequencing;Disulfide bond;Glycoprotein;Lipid-binding;Reference proteome;Secreted;Signal |
| Interact With | |
| Induction | INDUCTION: Repressed by the androgen dihydrotesterone (DHT), the estrogen estradiol (E2) and the thyroid hormone triiodothyronine (T3) (at protein level). {ECO:0000269|PubMed:17141562}. |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17141562}. Note=Secreted by the female lacrimal gland into tears. {ECO:0000269|PubMed:17141562}. |
| Modified Residue | |
| Post Translational Modification | PTM: N-glycosylated. {ECO:0000269|PubMed:17141562}. |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000269|PubMed:17141562 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 44,666 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |