| IED ID | IndEnz0005000783 |
| Enzyme Type ID | lipase000783 |
| Protein Name |
Platelet-activating factor acetylhydrolase homolog 2 EC 3.1.1.47 |
| Gene Name | paf-2 C52B9.7 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MGSYISSPQVLTRQVSGQFQVGCKDLMIDGTVLGDRGLFMRLYFPTDSQAADISSYPLWLPKPQYAHGLGEYLGQSSQKMNVITSTVVGEKREDCIENAQMSTKCDKWPIVVFSHGLGGSRTFYSTYCTSLASHGYVVAAVEHKDHSACWTYQLTEKNGELVEQPIKIKLIEKNEKNEFKIRNQQVGKRVTECVKALNVLEQLNLGTVPEKVLIGNDYNWAQFKNKLVMSSASVIGHSFGGATSLASSAYTTDFQKAIVFDGWMYPLDSTQQEQAKQPTLFLNVGDWQWNENLDVMKKIISHNDGNLALTLNGAVHQCFSDFPFIFPSWLAKKFGVQGRTEPSLCMQAAIELSLAFLENGKDGAQKLKDEKFSSFISNEIYGREKYKL |
| Enzyme Length | 388 |
| Uniprot Accession Number | Q22943 |
| Absorption | |
| Active Site | ACT_SITE 238; /note=Nucleophile; /evidence=ECO:0000250; ACT_SITE 261; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 316; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+); Xref=Rhea:RHEA:17777, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:30909, ChEBI:CHEBI:36707; EC=3.1.1.47; |
| DNA Binding | |
| EC Number | 3.1.1.47 |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Alternative sequence (2); Chain (1) |
| Keywords | Alternative splicing;Hydrolase;Lipid degradation;Lipid metabolism;Reference proteome |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10778742; 11231151; 11381264; 15340150; 20439776; 21177967; 22267497; 22286215; 22560298; 23800452; 24884423; 25487147; 6593563; |
| Motif | |
| Gene Encoded By | |
| Mass | 43,418 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:17777 |
| Cross Reference Brenda | 3.1.1.47; |