Detail Information for IndEnz0005000862
IED ID IndEnz0005000862
Enzyme Type ID lipase000862
Protein Name Oxysterols receptor LXR-alpha
Liver X receptor alpha
Nuclear receptor subfamily 1 group H member 3
RLD-1
Gene Name Nr1h3 Lxra
Organism Rattus norvegicus (Rat)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat)
Enzyme Sequence MSLWLEAAVPDVSPDSATELWKTEPQDAGDQGGNTCILREEARMPQSTGGALRIGLESSEPTALLPRAETLPEPTELRPQKRKKGPAPKMLGNELCSVCGDKASAFHYNVLSCEGCKGFFRRSVIKGARYICHSGGHCPMDTYMRRKCQECRLRKCRHAGMREECVLSEEQIRLKKLKRQEEEQAQATSVSPRVSSPPQVLPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPIAPDPQSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRSMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSINHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
Enzyme Length 445
Uniprot Accession Number Q62685
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding DNA_BIND 93..168; /note=Nuclear receptor; /evidence=ECO:0000255|PROSITE-ProRule:PRU00407
EC Number
Enzyme Function FUNCTION: Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (By similarity). Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). {ECO:0000250|UniProtKB:Q13133, ECO:0000250|UniProtKB:Q9Z0Y9}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Compositional bias (1); DNA binding (1); Domain (1); Modified residue (1); Region (5); Zinc finger (2)
Keywords Activator;Cytoplasm;DNA-binding;Metal-binding;Nucleus;Phosphoprotein;Receptor;Reference proteome;Transcription;Transcription regulation;Ubl conjugation;Zinc;Zinc-finger
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Z0Y9, ECO:0000255|PROSITE-ProRule:PRU00407}. Cytoplasm {ECO:0000250|UniProtKB:Q9Z0Y9}.
Modified Residue MOD_RES 191; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:22673903
Post Translational Modification PTM: Ubiquitinated leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:Q9Z0Y9}.
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 11781314; 16773041; 25263431; 25612518;
Motif
Gene Encoded By
Mass 50,555
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda