| IED ID | IndEnz0005000891 |
| Enzyme Type ID | lipase000891 |
| Protein Name |
Lysophospholipase VolA Vibrio outer membrane lysophospholipase A |
| Gene Name | volA VC_A0863 |
| Organism | Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) |
| Taxonomic Lineage | cellular organisms Bacteria Proteobacteria Gammaproteobacteria Vibrionales Vibrionaceae Vibrio Vibrio cholerae Vibrio cholerae O1 Vibrio cholerae O1 biovar El Tor Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) |
| Enzyme Sequence | MKQVIKLSLLCSALWLAGCGDETNSSGASTEVVYESYIQQALQRDTTIKFALSGKDANVPLPSFALMNAKDGTLEIPPGSNTSGSNPLVAMGQVDGWPITMPLFLDFKGAGLADNIITSGIYLYELTDSMTGSPSIKALLTNGVDYTAVSSAASDKILIMPTKALNASSEYILAVTSEVSDANGNPVGTSASYAALKSKNKIYSEGDIATLQKVTQGVEKIFQLSGVDETQIVYSTWFSTQSVSNTLFATRGATASAFASGSNQLETVWKQTGLGLDTAYTIQLGTPVDFAAALTADDNFSTYVGADKKTAILGTYTANTVDVTKGTVRLPYYLETGSNWNTQPFESAMPSLAKIKAALADSKEQLTIGSQLLAAGIDTTKLATDASEQLKLMGLTLTKSDGTALDPERYITRYSPVPKVKSVQDVPFLLFTPAGAAPTDIVIYQHGVTTAKENAYAFAKNLTAVGLAVIAIDLPLHGERSLDSTRSANSDPLAYINLTYLAVARDNLRQSILDVLGLRAALTLSQPLFTGTRLSGINVGTGSKVRMLGHSLGGIVGTSAIAESNKTLGSTAADAMYSFSGAAIQNSGGQISNLLLGSAFFGPKIKHNVALSASTEYKGFADAQCASLDDSACYNLFTSLATQEQLAQVTSGFQMFSYAAQTLLDTIDPYSVVSTKLNNGGLTTPLYFSEVDGDSVVPNKVSNPTGSLVYLSPQFAGTEPLATLLGLTTVNAGQTAPNATKSFVQFNSTAKHSTFVAPQDAGYADLAHHTEMQTETADFLADDSLGAVSNSNSVLK |
| Enzyme Length | 796 |
| Uniprot Accession Number | Q9KL83 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Required for the utilization of the prevalent host lipid lysophosphatidylcholine (LPC). Functions as a lipase that cleaves exogenous LPC and generates free fatty acids, which are then transported into the cell by fatty acid transporters such as FadL, and used in various metabolic pathways. {ECO:0000269|PubMed:23674613}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Lipidation (2); Mutagenesis (1); Signal peptide (1) |
| Keywords | Cell outer membrane;Lipid metabolism;Lipoprotein;Membrane;Palmitate;Reference proteome;Signal |
| Interact With | |
| Induction | INDUCTION: Induced in the presence of LPC. {ECO:0000269|PubMed:23674613}. |
| Subcellular Location | SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|PubMed:23674613}; Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303, ECO:0000269|PubMed:23674613}. Note=Surface-exposed. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..18; /evidence=ECO:0000255|PROSITE-ProRule:PRU00303 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 83,562 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |