| IED ID | IndEnz0005000918 |
| Enzyme Type ID | lipase000918 |
| Protein Name |
Vitellogenin-2 Vitellogenin II Yolk protein 2 |
| Gene Name | Yp2 CG2979 |
| Organism | Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
| Enzyme Sequence | MNPLRTLCVMACLLAVAMGNPQSGNRSGRRSNSLDNVEQPSNWVNPREVEELPNLKEVTLKKLQEMSLEEGATLLDKLYHLSQFNHVFKPDYTPEPSQIRGYIVGERGQKIEFNLNTLVEKVKRQQKFGDDEVTIFIQGLPETNTQVQKATRKLVQAYQQRYNLQPYETTDYSNEEQSQRSSSEEQQTQRRKQNGEQDDTKTGDLIVIQLGNAIEDFEQYATLNIERLGEIIGNRLVELTNTVNVPQEIIHLIGSGPAAHVAGVAGRQFTRQTGHKLRRITALDPTKIYGKPEERLTGLARGDADFVDAIHTSAYGMGTSQRLANVDFFPNGPSTGVPGADNVVEATMRATRYFAESVRPGNERNFPSVAASSYQEYKQNKGYGKRGYMGIATDFDLQGDYILQVNSKSPFGRSTPAQKQTGYHQVHQPWRQSSSNQGSRRQ |
| Enzyme Length | 442 |
| Uniprot Accession Number | P02844 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (3); Modified residue (10); Region (3); Sequence conflict (1); Signal peptide (1) |
| Keywords | Direct protein sequencing;Phosphoprotein;Reference proteome;Secreted;Signal;Sulfation |
| Interact With | |
| Induction | INDUCTION: By beta-ecdysone; in males. |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | MOD_RES 31; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18327897; MOD_RES 33; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18327897; MOD_RES 82; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18327897; MOD_RES 170; /note=Phosphothreonine; /evidence=ECO:0000269|PubMed:18327897; MOD_RES 172; /note=Sulfotyrosine; /evidence=ECO:0000269|PubMed:3139663; MOD_RES 173; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18327897; MOD_RES 178; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18327897; MOD_RES 181; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18327897; MOD_RES 182; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18327897; MOD_RES 183; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18327897 |
| Post Translational Modification | PTM: Tyrosine sulfation occurs in the female only and plays an essential functional role. {ECO:0000269|PubMed:3139663, ECO:0000269|PubMed:3922974}. |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 102718; 10363785; 10385622; 10648226; 10757764; 10823947; 10978290; 10978302; 11063693; 11095759; 111243; 11230529; 11230530; 11356418; 11370742; 11401455; 11420372; 11494318; 12136017; 12225917; 12350340; 12374736; 12590347; 12626737; 12733664; 12769890; 1367435; 1426625; 14504657; 14605208; 14673649; 1485963; 1487828; 15186491; 15221030; 1532159; 15342510; 15890189; 15955846; 16099838; 16163709; 16515779; 16934145; 16938865; 1696317; 16979555; 17191346; 17199047; 17292389; 17374649; 17419993; 1745231; 18039034; 18077584; 18433294; 18560591; 18562649; 18660538; 1879561; 1899669; 1902206; 1903120; 1907913; 1909423; 19171941; 19340310; 19453766; 19463195; 19503609; 19540341; 19704789; 1976473; 20220848; 20525996; 20530634; 20818332; 21074052; 2113880; 2115478; 21443682; 21447707; 21652649; 22384353; 22398720; 22496733; 22578134; 22760232; 22884528; 23071443; 23416132; 23550122; 23866071; 24206451; 2423251; 24475130; 24556521; 24682282; 2494181; 2495205; 2503417; 25081570; 25246242; 25426014; 25596379; 2606354; 26151218; 26173873; 26265702; 26335107; 26395483; 26551273; 26801178; 26952985; 27172187; 27794539; 28202685; 28306022; 28565154; 2903043; 29290392; 2996001; 30036827; 3029679; 30382186; 3072724; 30877919; 3089870; 3096733; 3114046; 3139664; 3145403; 3145737; 31799578; 32468146; 33163493; 33542461; 33827210; 33891588; 33892078; 3811009; 3919395; 3929763; 3936475; 3938365; 404389; 4203856; 6172303; 6193215; 6198419; 6262726; 6272212; 6275360; 6283091; 6418585; 6774810; 6775992; 6776130; 6777047; 6777217; 6793807; 6806142; 6815707; 7569915; 7651324; 7713409; 7789765; 7893138; 7980478; 8029823; 8223255; 8337758; 8355601; 8455566; 8524261; 8557045; 8575244; 8583899; 8606006; 8612957; 8612959; 86471; 8660436; 8676877; 8790328; 8896375; 8913769; 8952085; 8957000; 9115431; 9150263; 9215559; 9321417; 9342399; 9402735; 9549089; 9636079; 9692232; 9729879; 9819559; |
| Motif | |
| Gene Encoded By | |
| Mass | 49,660 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |