| IED ID |
IndEnz0005000921 |
| Enzyme Type ID |
lipase000921 |
| Protein Name |
Rho-related GTP-binding protein RhoC
|
| Gene Name |
RHOC ARHC |
| Organism |
Bos taurus (Bovine) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Sarcopterygii
Dipnotetrapodomorpha
Tetrapoda
Amniota
Mammalia
Theria
Eutheria
Boreoeutheria
Laurasiatheria
Artiodactyla
Ruminantia
Pecora
Bovidae
Bovinae
Bos (oxen
cattle)
Bos taurus (Bovine)
|
| Enzyme Sequence |
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQVRKNKRRRGCPIL |
| Enzyme Length |
193 |
| Uniprot Accession Number |
Q1RMJ6 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells (By similarity). {ECO:0000250}. |
| Temperature Dependency |
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| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
NP_BIND 12..19; /note=GTP; /evidence=ECO:0000250; NP_BIND 59..63; /note=GTP; /evidence=ECO:0000250; NP_BIND 117..120; /note=GTP; /evidence=ECO:0000250 |
| Features |
Chain (1); Lipidation (1); Modified residue (1); Motif (1); Nucleotide binding (3); Propeptide (1) |
| Keywords |
Cell membrane;GTP-binding;Lipoprotein;Membrane;Methylation;Nucleotide-binding;Prenylation;Reference proteome |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cleavage furrow {ECO:0000250}. Note=Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. {ECO:0000250}. |
| Modified Residue |
MOD_RES 190; /note=Cysteine methyl ester; /evidence=ECO:0000250 |
| Post Translational Modification |
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| Signal Peptide |
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| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
MOTIF 34..42; /note=Effector region; /evidence=ECO:0000255 |
| Gene Encoded By |
|
| Mass |
22,006 |
| Kinetics |
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| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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