Detail Information for IndEnz0005000933
IED ID IndEnz0005000933
Enzyme Type ID lipase000933
Protein Name Lipase member N
EC 3.1.1.-
Lipase-like abhydrolase domain-containing protein 4
Gene Name Lipn Lipl4
Organism Mus musculus (Mouse)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse)
Enzyme Sequence MPMMWLFLTTACLIPGTLSAGGFLDFENKVNPEVWMNASEIIMYNGYPSEEYDVTTADGYILAINRIPHGRAQTGQTGPRPVVYMQHALFADNAYWLENFANGSLGFILADAGYDVWMGNSRGNTWSRRHKTLSANEEKFWAFSFNEMAKYDLPGIIDFIVNKTGQEKLYFIGHSLGTTIGFVAFSTMPELAQRIKMNFALGPVISFKYPTSVFTNLFLLPKSIIKLVFGTKGVLLEDKNARMSFITFCNQKLLQPLCSEFMSLWAGFNKKNMNMSRLDVYMAHAPTGSSIQNMLHIKQLYRSDEFRAYDWGSEAENMNHYNQSYPPLYDLTAMKVPTAIWAGGHDVLVTPQDVARILPQITNLRYFKQFPDWNHFDFVWGLDAPQRLYSKIISLMKEYF
Enzyme Length 400
Uniprot Accession Number Q3U4B4
Absorption
Active Site ACT_SITE 175; /note=Nucleophile; /evidence=ECO:0000250; ACT_SITE 346; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU10037; ACT_SITE 375; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU10037
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.1.1.-
Enzyme Function FUNCTION: Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers (By similarity). {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Disulfide bond (1); Domain (1); Glycosylation (1); Signal peptide (1)
Keywords Disulfide bond;Glycoprotein;Hydrolase;Lipid degradation;Lipid metabolism;Reference proteome;Secreted;Signal
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..19; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 11217851; 12466851; 24194600; 27626380; 28369476; 28700664;
Motif
Gene Encoded By
Mass 45,744
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda