| IED ID | IndEnz0005000935 |
| Enzyme Type ID | lipase000935 |
| Protein Name |
Neuroligin-4, X-linked Neuroligin X HNLX |
| Gene Name | NLGN4X KIAA1260 NLGN4 UNQ365/PRO701 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MSRPQGLLWLPLLFTPVCVMLNSNVLLWLTALAIKFTLIDSQAQYPVVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGCNMLDTTDMVECLRNKNYKELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNLNEIFQYVSTTTKVPPPDMTSFPYGTRRSPAKIWPTTKRPAITPANNPKHSKDPHKTGPEDTTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHETHRRPSPQRNTTNDIAHIQNEEIMSLQMKQLEHDHECESLQAHDTLRLTCPPDYTLTLRRSPDDIPLMTPNTITMIPNTLTGMQPLHTFNTFSGGQNSTNLPHGHSTTRV |
| Enzyme Length | 816 |
| Uniprot Accession Number | Q8N0W4 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Putative neuronal cell surface protein involved in cell-cell-interactions. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (1); Beta strand (20); Chain (1); Disulfide bond (3); Erroneous initiation (1); Glycosylation (2); Helix (26); Modified residue (1); Natural variant (1); Region (2); Sequence conflict (1); Signal peptide (1); Topological domain (2); Transmembrane (1); Turn (8) |
| Keywords | 3D-structure;Alternative splicing;Asperger syndrome;Autism;Autism spectrum disorder;Cell adhesion;Cell junction;Cell membrane;Direct protein sequencing;Disulfide bond;Glycoprotein;Membrane;Phosphoprotein;Postsynaptic cell membrane;Reference proteome;Signal;Synapse;Transmembrane;Transmembrane helix |
| Interact With | Q63373-3 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic density membrane. |
| Modified Residue | MOD_RES 712; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q62889 |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..41; /evidence=ECO:0000269|PubMed:15340161 |
| Structure 3D | X-ray crystallography (3) |
| Cross Reference PDB | 2WQZ; 2XB6; 3BE8; |
| Mapped Pubmed ID | 10433268; 10433269; 10806096; 11498055; 11604393; 15274046; 15389766; 15540461; 15622415; 16077734; 16242404; 16508939; 16624946; 16648374; 16846852; 17292328; 17897391; 18189281; 18231125; 18628683; 18812509; 18829961; 19058789; 19125102; 19260141; 19545860; 19598235; 19645625; 19726642; 19736351; 20436377; 20543817; 20711500; 20714171; 21278334; 21282647; 22948383; 23431752; 23710042; 23851596; 24439376; 24570023; 25378172; 25675530; 27782075; 28948087; 29123130; 29244827; 29622757; 31257103; 32243781; 32873342; 33268543; 33369065; 7695896; 7736595; 8576240; 9024696; 9115257; 9221768; 9927700; |
| Motif | |
| Gene Encoded By | |
| Mass | 91,915 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |