Detail Information for IndEnz0005000953
IED ID IndEnz0005000953
Enzyme Type ID lipase000953
Protein Name Patatin-like phospholipase domain-containing protein 2
EC 3.1.1.3
Adipose triglyceride lipase
Calcium-independent phospholipase A2
Desnutrin
IPLA2-zeta
Pigment epithelium-derived factor
TTS2.2
Transport-secretion protein 2
TTS2
Gene Name PNPLA2 ATGL FP17548
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MFPREKTWNISFAGCGFLGVYYVGVASCLREHAPFLVANATHIYGASAGALTATALVTGVCLGEAGAKFIEVSKEARKRFLGPLHPSFNLVKIIRSFLLKVLPADSHEHASGRLGISLTRVSDGENVIISHFNSKDELIQANVCSGFIPVYCGLIPPSLQGVRYVDGGISDNLPLYELKNTITVSPFSGESDICPQDSSTNIHELRVTNTSIQFNLRNLYRLSKALFPPEPLVLREMCKQGYRDGLRFLQRNGLLNRPNPLLALPPARPHGPEDKDQAVESAQAEDYSQLPGEDHILEHLPARLNEALLEACVEPTDLLTTLSNMLPVRLATAMMVPYTLPLESALSFTIRLLEWLPDVPEDIRWMKEQTGSICQYLVMRAKRKLGRHLPSRLPEQVELRRVQSLPSVPLSCAAYREALPGWMRNNLSLGDALAKWEECQRQLLLGLFCTNVAFPPEALRMRAPADPAPAPADPASPQHQLAGPAPLLSTPAPEARPVIGALGL
Enzyme Length 504
Uniprot Accession Number Q96AD5
Absorption
Active Site ACT_SITE 47; /note=Nucleophile; /evidence=ECO:0000255|PROSITE-ProRule:PRU01161; ACT_SITE 166; /note=Proton acceptor; /evidence=ECO:0000255|PROSITE-ProRule:PRU01161
Activity Regulation ACTIVITY REGULATION: Inhibited by BEL ((E)-6-(bromomethylene)-3-(1-naphthalenyl)-2H-tetrahydropyran-2-one), a suicide substrate inhibitor. No differences in enzymatic activity that uses (1,2-dilinoleoyl)-phosphatidylcholine as substrate was detected in the presence or absence of ATP. Activated by ABHD5 and SERPINF1. {ECO:0000269|PubMed:15364929, ECO:0000269|PubMed:17032652}.
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3; Evidence={ECO:0000269|PubMed:15550674, ECO:0000269|PubMed:16150821, ECO:0000269|PubMed:17603008};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12045; Evidence={ECO:0000305|PubMed:15550674, ECO:0000305|PubMed:16150821, ECO:0000305|PubMed:17603008}; CATALYTIC ACTIVITY: Reaction=a triacyl-sn-glycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:44864, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:49172, ChEBI:CHEBI:64615; Evidence={ECO:0000269|PubMed:17603008};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44865; Evidence={ECO:0000305|PubMed:17603008}; CATALYTIC ACTIVITY: Reaction=a triacyl-sn-glycerol + H2O = 1,3-diacyl-sn-glycerol + a fatty acid + H(+); Xref=Rhea:RHEA:43732, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:64615, ChEBI:CHEBI:77272; Evidence={ECO:0000269|PubMed:17603008, ECO:0000305|PubMed:15550674};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43733; Evidence={ECO:0000305|PubMed:15550674, ECO:0000305|PubMed:17603008}; CATALYTIC ACTIVITY: Reaction=a triacyl-sn-glycerol + H2O = a 2,3-diacyl-sn-glycerol + a fatty acid + H(+); Xref=Rhea:RHEA:38499, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:64615, ChEBI:CHEBI:75524; Evidence={ECO:0000250|UniProtKB:Q8BJ56};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38500; Evidence={ECO:0000250|UniProtKB:Q8BJ56}; CATALYTIC ACTIVITY: Reaction=a 1,3-diacylglycerol + a 1-acylglycerol = a triacylglycerol + glycerol; Xref=Rhea:RHEA:44440, ChEBI:CHEBI:17754, ChEBI:CHEBI:17855, ChEBI:CHEBI:35759, ChEBI:CHEBI:47777; Evidence={ECO:0000269|PubMed:15364929};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44441; Evidence={ECO:0000305|PubMed:15364929}; CATALYTIC ACTIVITY: Reaction=a 1,2-diacylglycerol + a 1-acylglycerol = a triacylglycerol + glycerol; Xref=Rhea:RHEA:44436, ChEBI:CHEBI:17754, ChEBI:CHEBI:17855, ChEBI:CHEBI:35759, ChEBI:CHEBI:49172; Evidence={ECO:0000269|PubMed:15364929};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44437; Evidence={ECO:0000305|PubMed:15364929}; CATALYTIC ACTIVITY: Reaction=2 a 1-acylglycerol = a 1,2-diacylglycerol + glycerol; Xref=Rhea:RHEA:44432, ChEBI:CHEBI:17754, ChEBI:CHEBI:35759, ChEBI:CHEBI:49172; Evidence={ECO:0000269|PubMed:15364929};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44433; Evidence={ECO:0000305|PubMed:15364929}; CATALYTIC ACTIVITY: Reaction=a triacyl-sn-glycerol + all-trans-retinol = a diacylglycerol + an all-trans-retinyl ester; Xref=Rhea:RHEA:44676, ChEBI:CHEBI:17336, ChEBI:CHEBI:18035, ChEBI:CHEBI:63410, ChEBI:CHEBI:64615; Evidence={ECO:0000269|PubMed:17603008};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44677; Evidence={ECO:0000305|PubMed:17603008}; CATALYTIC ACTIVITY: Reaction=(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O; Xref=Rhea:RHEA:38379, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:52323, ChEBI:CHEBI:53753; Evidence={ECO:0000269|PubMed:17603008, ECO:0000305|PubMed:15550674};PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:38381; Evidence={ECO:0000305|PubMed:15550674, ECO:0000305|PubMed:17603008}; CATALYTIC ACTIVITY: Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1,3-di-(9Z-octadecenoyl)-glycerol + H(+); Xref=Rhea:RHEA:38387, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:53753, ChEBI:CHEBI:75735; Evidence={ECO:0000269|PubMed:17603008};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38388; Evidence={ECO:0000305|PubMed:17603008}; CATALYTIC ACTIVITY: Reaction=1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol; Xref=Rhea:RHEA:38331, ChEBI:CHEBI:17754, ChEBI:CHEBI:53753, ChEBI:CHEBI:75342, ChEBI:CHEBI:75735; Evidence={ECO:0000269|PubMed:15364929};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38332; Evidence={ECO:0000305|PubMed:15364929}; CATALYTIC ACTIVITY: Reaction=1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol; Xref=Rhea:RHEA:38327, ChEBI:CHEBI:17754, ChEBI:CHEBI:52323, ChEBI:CHEBI:53753, ChEBI:CHEBI:75342; Evidence={ECO:0000269|PubMed:15364929};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38328; Evidence={ECO:0000305|PubMed:15364929}; CATALYTIC ACTIVITY: Reaction=2 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + glycerol; Xref=Rhea:RHEA:38323, ChEBI:CHEBI:17754, ChEBI:CHEBI:52323, ChEBI:CHEBI:75342; Evidence={ECO:0000269|PubMed:15364929};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38324; Evidence={ECO:0000305|PubMed:15364929}; CATALYTIC ACTIVITY: Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol; Xref=Rhea:RHEA:39987, ChEBI:CHEBI:17336, ChEBI:CHEBI:53753, ChEBI:CHEBI:70760, ChEBI:CHEBI:75945; Evidence={ECO:0000269|PubMed:17603008};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39988; Evidence={ECO:0000305|PubMed:17603008}; CATALYTIC ACTIVITY: Reaction=1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O = (9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+); Xref=Rhea:RHEA:38395, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:75841, ChEBI:CHEBI:75849; Evidence={ECO:0000250|UniProtKB:Q8BJ56};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38396; Evidence={ECO:0000250|UniProtKB:Q8BJ56}; CATALYTIC ACTIVITY: Reaction=1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = (9Z,12Z)-octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+); Xref=Rhea:RHEA:38403, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:75844, ChEBI:CHEBI:75850; Evidence={ECO:0000250|UniProtKB:Q8BJ56};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38404; Evidence={ECO:0000250|UniProtKB:Q8BJ56}; CATALYTIC ACTIVITY: Reaction=1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O = (9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + H(+); Xref=Rhea:RHEA:38411, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32387, ChEBI:CHEBI:75845, ChEBI:CHEBI:75852; Evidence={ECO:0000250|UniProtKB:Q8BJ56};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38412; Evidence={ECO:0000250|UniProtKB:Q8BJ56}; CATALYTIC ACTIVITY: Reaction=1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O = 1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate; Xref=Rhea:RHEA:38419, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:75735, ChEBI:CHEBI:75846; Evidence={ECO:0000250|UniProtKB:Q8BJ56};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38420; Evidence={ECO:0000250|UniProtKB:Q8BJ56}; CATALYTIC ACTIVITY: Reaction=1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H(+); Xref=Rhea:RHEA:38423, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75583, ChEBI:CHEBI:75867; Evidence={ECO:0000250|UniProtKB:Q8BJ56};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38424; Evidence={ECO:0000250|UniProtKB:Q8BJ56}; CATALYTIC ACTIVITY: Reaction=1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+); Xref=Rhea:RHEA:38647, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75847, ChEBI:CHEBI:75868; Evidence={ECO:0000250|UniProtKB:Q8BJ56};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38648; Evidence={ECO:0000250|UniProtKB:Q8BJ56}; CATALYTIC ACTIVITY: Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+); Xref=Rhea:RHEA:38391, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:53753, ChEBI:CHEBI:75824; Evidence={ECO:0000250|UniProtKB:Q8BJ56};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38392; Evidence={ECO:0000250|UniProtKB:Q8BJ56}; CATALYTIC ACTIVITY: Reaction=1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O = (9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+); Xref=Rhea:RHEA:38399, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:75841, ChEBI:CHEBI:75853; Evidence={ECO:0000250|UniProtKB:Q8BJ56};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38400; Evidence={ECO:0000250|UniProtKB:Q8BJ56}; CATALYTIC ACTIVITY: Reaction=1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = (9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+); Xref=Rhea:RHEA:38407, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:75844, ChEBI:CHEBI:75854; Evidence={ECO:0000250|UniProtKB:Q8BJ56};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38408; Evidence={ECO:0000250|UniProtKB:Q8BJ56}; CATALYTIC ACTIVITY: Reaction=1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O = (9Z,12Z,15Z)-octadecatrienoate + 2,3-di-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycerol + H(+); Xref=Rhea:RHEA:38415, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32387, ChEBI:CHEBI:75845, ChEBI:CHEBI:75855; Evidence={ECO:0000250|UniProtKB:Q8BJ56};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38416; Evidence={ECO:0000250|UniProtKB:Q8BJ56}; CATALYTIC ACTIVITY: Reaction=1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O = (9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+); Xref=Rhea:RHEA:38431, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75846, ChEBI:CHEBI:75870; Evidence={ECO:0000250|UniProtKB:Q8BJ56};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38432; Evidence={ECO:0000250|UniProtKB:Q8BJ56}; CATALYTIC ACTIVITY: Reaction=1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) + hexadecanoate; Xref=Rhea:RHEA:38427, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:75824, ChEBI:CHEBI:75847; Evidence={ECO:0000250|UniProtKB:Q8BJ56};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38428; Evidence={ECO:0000250|UniProtKB:Q8BJ56}; CATALYTIC ACTIVITY: Reaction=1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+); Xref=Rhea:RHEA:38643, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75546, ChEBI:CHEBI:75583; Evidence={ECO:0000250|UniProtKB:Q8BJ56};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38644; Evidence={ECO:0000250|UniProtKB:Q8BJ56};
DNA Binding
EC Number 3.1.1.3
Enzyme Function FUNCTION: Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15550674, PubMed:15364929, PubMed:16150821). Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone (By similarity). Also has acylglycerol transacylase activity. Acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade (By similarity). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides (PubMed:17603008). Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926). May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (By similarity). {ECO:0000250|UniProtKB:Q8BJ56, ECO:0000269|PubMed:15364929, ECO:0000269|PubMed:15550674, ECO:0000269|PubMed:16150821, ECO:0000269|PubMed:16239926, ECO:0000269|PubMed:17603008}.
Temperature Dependency
PH Dependency BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 7.5 with (1,2-dilinoleoyl)-phosphatidylcholine as substrate. {ECO:0000269|PubMed:17032652};
Pathway PATHWAY: Glycerolipid metabolism; triacylglycerol degradation.
nucleotide Binding
Features Active site (2); Alternative sequence (1); Chain (1); Domain (1); Erroneous initiation (2); Frameshift (1); Glycosylation (1); Modified residue (3); Motif (3); Mutagenesis (1); Natural variant (4); Region (1); Sequence conflict (7); Topological domain (2); Transmembrane (1)
Keywords Alternative splicing;Cell membrane;Disease variant;Glycoprotein;Hydrolase;Lipid degradation;Lipid droplet;Lipid metabolism;Membrane;Phosphoprotein;Reference proteome;Signal-anchor;Transmembrane;Transmembrane helix
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Lipid droplet. Cell membrane; Single-pass type II membrane protein.
Modified Residue MOD_RES 372; /note="Phosphoserine; in vitro"; /evidence="ECO:0000250|UniProtKB:Q8BJ56"; MOD_RES 404; /note="Phosphoserine; by PKA and FAM20C"; /evidence="ECO:0000269|PubMed:22733971, ECO:0000269|PubMed:26091039, ECO:0007744|PubMed:23186163"; MOD_RES 428; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569"
Post Translational Modification PTM: Phosphorylation at Ser-404 by PKA is increased during fasting and moderate intensity exercise, and moderately increases lipolytic activity (By similarity). Phosphorylation at Ser-404 is increased upon beta-adrenergic stimulation. {ECO:0000250, ECO:0000269|PubMed:22733971}.
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 15231748; 16169070; 16679289; 16752181; 17327373; 17356053; 17609260; 17631826; 17657808; 18072017; 18191271; 18224330; 18445597; 18445677; 18952067; 18952573; 19010445; 19061969; 19106247; 19390624; 19401457; 19433586; 19692632; 19695247; 20029029; 20034933; 20167152; 20237999; 20370797; 20711500; 20832801; 21068004; 21073837; 21129760; 21170305; 21393244; 21498783; 21543206; 21544567; 21613358; 21680814; 21757733; 21789191; 21828047; 21900206; 22183409; 22535977; 22713505; 22832386; 22990388; 23232698; 23818523; 23824421; 23827855; 24332944; 24440819; 24742676; 25036637; 25054327; 25114172; 25177954; 25258314; 25700221; 25956450; 25985012; 26318046; 26330055; 26500201; 26600210; 26803235; 26882978; 26922712; 27213586; 27559856; 27635633; 27851965; 28179319; 28391974; 29072982; 29146190; 29320510; 29457907; 29472527; 29539587; 29764424; 30367149; 30754064; 30918066; 30926171; 31147543; 31476254; 31525260; 31610914; 31757217; 32404277; 32542055; 32685558; 32777979; 32818550; 33064888; 33160079; 33445064; 33621408; 33824421; 34387896;
Motif MOTIF 14..19; /note=GXGXXG; /evidence=ECO:0000255|PROSITE-ProRule:PRU01161; MOTIF 45..49; /note=GXSXG; /evidence=ECO:0000255|PROSITE-ProRule:PRU01161; MOTIF 166..168; /note=DGA/G; /evidence=ECO:0000255|PROSITE-ProRule:PRU01161
Gene Encoded By
Mass 55,316
Kinetics
Metal Binding
Rhea ID RHEA:12044; RHEA:12045; RHEA:44864; RHEA:44865; RHEA:43732; RHEA:43733; RHEA:38499; RHEA:38500; RHEA:44440; RHEA:44441; RHEA:44436; RHEA:44437; RHEA:44432; RHEA:44433; RHEA:44676; RHEA:44677; RHEA:38379; RHEA:38381; RHEA:38387; RHEA:38388; RHEA:38331; RHEA:38332; RHEA:38327; RHEA:38328; RHEA:38323; RHEA:38324; RHEA:39987; RHEA:39988; RHEA:38395; RHEA:38396; RHEA:38403; RHEA:38404; RHEA:38411; RHEA:38412; RHEA:38419; RHEA:38420; RHEA:38423; RHEA:38424; RHEA:38647; RHEA:38648; RHEA:38391; RHEA:38392; RHEA:38399; RHEA:38400; RHEA:38407; RHEA:38408; RHEA:38415; RHEA:38416; RHEA:38431; RHEA:38432; RHEA:38427; RHEA:38428; RHEA:38643; RHEA:38644
Cross Reference Brenda