| IED ID | IndEnz0005000973 |
| Enzyme Type ID | lipase000973 |
| Protein Name |
Vitellogenin-1 Vitellogenin I Yolk protein 1 |
| Gene Name | Yp1 CG2985 |
| Organism | Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
| Enzyme Sequence | MNPMRVLSLLACLAVAALAKPNGRMDNSVNQALKPSQWLSGSQLEAIPALDDFTIERLENMNLERGAELLQQVYHLSQIHHNVEPNYVPSGIQVYVPKPNGDKTVAPLNEMIQRLKQKQNFGEDEVTIIVTGLPQTSETVKKATRKLVQAYMQRYNLQQQRQHGKNGNQDYQDQSNEQRKNQRTSSEEDYSEEVKNAKTQSGDIIVIDLGSKLNTYERYAMLDIEKTGAKIGKWIVQMVNELDMPFDTIHLIGQNVGAHVAGAAAQEFTRLTGHKLRRVTGLDPSKIVAKSKNTLTGLARGDAEFVDAIHTSVYGMGTPIRSGDVDFYPNGPAAGVPGASNVVEAAMRATRYFAESVRPGNERSFPAVPANSLQQYKQNDGFGKRAYMGIDTAHDLEGDYILQVNPKSPFGRNAPAQKQSSYHGVHQAWNTNQDSKDYQ |
| Enzyme Length | 439 |
| Uniprot Accession Number | P02843 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (3); Modified residue (7); Region (2); Sequence conflict (1); Signal peptide (1) |
| Keywords | Phosphoprotein;Reference proteome;Secreted;Signal;Sulfation |
| Interact With | |
| Induction | INDUCTION: By beta-ecdysone; in males. |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | MOD_RES 171; /note=Phosphotyrosine; /evidence=ECO:0000269|PubMed:18327897; MOD_RES 175; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18327897; MOD_RES 185; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18327897; MOD_RES 186; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18327897; MOD_RES 190; /note=Phosphotyrosine; /evidence=ECO:0000269|PubMed:18327897; MOD_RES 191; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18327897; MOD_RES 435; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18327897 |
| Post Translational Modification | PTM: Tyrosine sulfation occurs in the female only and plays an essential functional role. {ECO:0000269|PubMed:3922974}. |
| Signal Peptide | SIGNAL 1..20 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10191049; 102718; 10357929; 10363785; 10430590; 10648226; 10757764; 10890889; 111243; 11139510; 11256069; 11356418; 11370742; 11494318; 12136017; 12225917; 12230547; 12350340; 12351791; 12374736; 12548287; 12573238; 12590347; 12769890; 12805208; 1367435; 1426625; 14504657; 14605208; 14673649; 14738738; 1485963; 14871609; 1487828; 15056610; 1508206; 15186491; 1532159; 15342510; 1547943; 1569958; 15890189; 15955846; 16099838; 16163709; 16169493; 16181521; 16934145; 16938865; 16979555; 17191346; 17199047; 17292389; 1730058; 1737619; 17419993; 1745231; 17507679; 1781031; 18039034; 18077584; 18433294; 18562649; 18660538; 1879561; 1899669; 1902206; 1903120; 19050045; 1907913; 1909423; 19137114; 19171941; 19453766; 19463195; 19503609; 19540341; 19704789; 1976473; 20122915; 20220848; 20433773; 20525996; 20530634; 20818332; 21074052; 2113880; 2115478; 21447707; 21652649; 21889502; 2198896; 22037703; 22384353; 22398720; 22496733; 22578134; 22623215; 22760232; 22884528; 23071443; 23173095; 23416132; 23462112; 23550122; 23866071; 24089336; 2423251; 24556521; 24658702; 24682282; 24865556; 2494181; 2495205; 25081570; 25246242; 25312911; 25596379; 2578322; 25797692; 25955646; 2606354; 26173873; 26265702; 26335107; 26395483; 26801178; 26896675; 26952985; 27172187; 27765625; 27794539; 28202685; 28306022; 2903043; 29290392; 29389999; 2996001; 30036827; 3029679; 30382186; 30534416; 3072724; 30877919; 3096733; 3114046; 3123886; 3139663; 31398343; 3145403; 3145737; 31799578; 32468146; 32778582; 33159074; 33163493; 33542461; 33827210; 33891588; 3919395; 3929763; 3936475; 3938365; 404389; 4203856; 6172303; 6193215; 6198419; 6262726; 6283091; 6405043; 6774810; 6775992; 6776130; 6777047; 6777217; 6793807; 6806142; 6815707; 6817923; 7286449; 7563071; 7569915; 7590251; 7651324; 7720712; 7851798; 7893138; 7980478; 8157678; 8223255; 8337758; 8422987; 8455566; 8524261; 8557045; 8606006; 8612957; 8612959; 86471; 8663250; 8676877; 8781184; 8790328; 9115431; 9150263; 9215559; 9243791; 9342399; 9545464; 9692232; 9698377; 9729879; 9878044; 9927589; |
| Motif | |
| Gene Encoded By | |
| Mass | 48,712 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |