Detail Information for IndEnz0005001006
IED ID IndEnz0005001006
Enzyme Type ID lipase001006
Protein Name Apolipoprotein A-IV
Apo-AIV
ApoA-IV
Apolipoprotein A4
Gene Name APOA4
Organism Phoca vitulina (Harbor seal)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Carnivora Caniformia Phocidae (true seals) Phoca Phoca vitulina (Harbor seal)
Enzyme Sequence MFLKAVVLTLSLVAVTGAQAEVSANQVATVVWDYFSQLSNNAKEAVEHLQKSELTQQLNALFQDKIGQVNTYTDNLQKKLVSFAMELHERLRKDSEKLKEEIRKELEELRAGLLPHADEVSRKIGDNMHELQQRLGPYAEELRTQVNTHAEHLRNQLTAHAQRMETTLRQNVGNLQASLTPYADELKAKIDQNVEELKGHLTPYADELKVKIDQNVEDLRRSLAPYAQDVQEKLNHQLEGLAFQMKKNAEELKAKISANADELRQKLVPVAEVVRGKLRDNTEELQKSLAELSSHLDRQVEEFRRNMGPYGETFNKALLQQVEELRQKLGPYAGDVEDHLSFLEKDLRDKVNSFFSTLEEKENQDMLVAVPELQLTPVPLES
Enzyme Length 382
Uniprot Accession Number P0DTS1
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons. {ECO:0000250|UniProtKB:P33621}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Region (1); Repeat (13); Signal peptide (1)
Keywords Chylomicron;HDL;Lipid transport;Phosphoprotein;Repeat;Secreted;Signal;Transport
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P33621}.
Modified Residue
Post Translational Modification PTM: Phosphorylation sites are present in the extracellular medium. {ECO:0000250}.
Signal Peptide SIGNAL 1..20; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 43,620
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda