Detail Information for IndEnz0005001022
IED ID IndEnz0005001022
Enzyme Type ID lipase001022
Protein Name Probable cholinesterase
EC 3.1.1.8
Acylcholine acylhydrolase
Gene Name MIMI_L906
Organism Acanthamoeba polyphaga mimivirus (APMV)
Taxonomic Lineage Viruses Varidnaviria Bamfordvirae Nucleocytoviricota Megaviricetes Imitervirales Mimiviridae Mimivirus Acanthamoeba polyphaga mimivirus (APMV)
Enzyme Sequence MTDHKIIMLLLLGIYCIQATQFTQVNIDNGPIKGTLQYVEGRAIRVFKGIPFAEPPVNNLRWKAPVPYTKKWHNPLNTTEYKPKCPQYVAPGTVPEPRGISEDCLYTNVWAPVPEYHGETFPVMVWIHGGAFISGSPEDFGVGNFSILAVTKRIIIVAASYRVNAFGFFSSELLGKSQLEARGVYGLLDQRLGLKWVKNNIAAFGGKSKDITIYGQSAGGISVCLQAVTPLNDLPGEKLFTRVIGSSGYCDILPMTNNSADAGLVQKLNCTTKECLYALPWQNITNAVGPGFLSFQPTVGINKFLPDQPISLLADRTNPRSKNFVPDIYMQGFTANEGTFVLYNYFPQTYDNPNTPGFPTQQMADALSIASGNYSAEFYYNDLAPLYSTEYNSNVTYPGQGFISRVDDIMACNTRRNMIYWQQSKKTKAHSWYFDSAPDTHIYPSWTKVFHESDVFYVARRCDGLWCTNLTCQQDNLGKTMNIYWNSAIRAASLTPKNKMDNLRDVPVWPQYGKNEVVMHFTAVGENKGPQTSVLFSSIISADGDYQYLQRCKILDRVRAEYYNIPALDPETYLNACSK
Enzyme Length 579
Uniprot Accession Number Q5UR02
Absorption
Active Site ACT_SITE 217; /note=Acyl-ester intermediate; /evidence=ECO:0000255|PROSITE-ProRule:PRU10039; ACT_SITE 337; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 451; /note=Charge relay system; /evidence=ECO:0000250
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=an acylcholine + H2O = a carboxylate + choline + H(+); Xref=Rhea:RHEA:21964, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:35287; EC=3.1.1.8;
DNA Binding
EC Number 3.1.1.8
Enzyme Function FUNCTION: May be involved in the disruption of the host membrane.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Glycosylation (8); Signal peptide (1)
Keywords Glycoprotein;Hydrolase;Reference proteome;Serine esterase;Signal
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..19; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 64,868
Kinetics
Metal Binding
Rhea ID RHEA:21964
Cross Reference Brenda