| IED ID | IndEnz0005001083 |
| Enzyme Type ID | lipase001083 |
| Protein Name |
GPI inositol-deacylase EC 3.1.-.- Bypass of SEC30 protein 1 |
| Gene Name | BST1 YFL025C |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces Saccharomyces cerevisiae (Baker's yeast) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Enzyme Sequence | MGIRRLVSVITRPIINKVNSSGQYSRVLATREDQDKASPKYMNNDKIAKKPYTYRLFSILGILSICSLLLISLLKPFNGADAPQCESIYMFPSYARIDGFDERYTPLAHKYHLYLYREQSVDREPLNGDELQLDGIPVLFIPGNAGSFRQCRSIASACSNIYFDSNTRATLRNENVRNLDFFTADFNEDFTAFHGETMLDQAEYLNDAIKYILSLYERTPDYPHPKPQSVIIVGHSMGGIVSRVMLTLKNHVPGSISTILTLSSPHAASPVTFDGDILKLYKNTNEYWRKQLSQNDSFFSKNISLVSITGGILDTTLPADYASVEDLVSLENGFTSFTTTIPDVWTPIDHLAIVWCKQLREVLARLLLESIDASKPEKVKPLNQRLQIARKLLLSGFEDYSWMNSKLNYPQENLQEFSDNFFSDYATLEMNDVLDFEMFNLEKWHNNYTKINIPSNISSTEHLHFTLLTSLDMPMIYFCTESRVNLSCITAVDSILTVPRSSKDTQFAADSSFGEAKNPFKAVSVGKNILQKYDYLMISKPTYGEFSEQEGMEDNQGFLLALLRNVSNVQIVNTTPSQILLFGEQLHLDGKDIEQVISFSNLWDSLLSYKLETKIEASNEGIASEETLFQPFIRQWVYEPFESKWHLNIINKSLDINMHNVAPFIPLNESEPRSLQLSFFIPPGMSLEAKMTINWSLTLKMLFIRYRLALASFPVAFIALVLSYQFYWYNKTSEFPSFDSTLGYILRKHGILMFFTLFLASPVVNNKLVQRILYLLDPVGLNYPFLLSERNMHANFYYLGIRDWFMSTIGILFGVMTVGLLALVSKIFGSLEILVIFLQRKLSKKNTEDKEAFDTIEHKAYGKGRLMASVLLLLLVFFHIPYQMAFVISLVIQIATCIRVALLKLSNNEQKLNLLNYNMTLLLLLLFVSAINIPIIIVFLHNVAIKWETSFRSHHNILAVAPIIFLVGNNSIFKMPNSVPLDTWDGKVTIILFVYLTVFSFIYGIRNLYWIHHLVNIICAWLLFFETIH |
| Enzyme Length | 1029 |
| Uniprot Accession Number | P43571 |
| Absorption | |
| Active Site | ACT_SITE 236; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.1.-.- |
| Enzyme Function | FUNCTION: Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins. Required for the transport of misfolded protein to the Golgi, although dipensable for the transport of many normal proteins. {ECO:0000269|PubMed:11673477, ECO:0000269|PubMed:14734546, ECO:0000269|PubMed:16319176, ECO:0000269|PubMed:8862519}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Glycosylation (11); Transmembrane (9) |
| Keywords | Endoplasmic reticulum;Glycoprotein;Hydrolase;Membrane;Protein transport;Reference proteome;Transmembrane;Transmembrane helix;Transport |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}. |
| Modified Residue | |
| Post Translational Modification | PTM: Glycosylated. {ECO:0000269|PubMed:8862519}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12096123; 12878605; 14690591; 16093310; 16859984; 17233591; 17361015; 17913366; 17989219; 18323404; 19054390; 19433630; 19536198; 19883648; 21266254; 21490136; 21603271; 22177309; 22194828; 22265715; 23135325; 23202731; 23209158; 24391512; 24784135; 24906797; 25936552; 26450970; 26456335; 26563290; 26646153; 27325793; 27462707; 27693354; |
| Motif | |
| Gene Encoded By | |
| Mass | 117,755 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |