Detail Information for IndEnz0005001099
IED ID IndEnz0005001099
Enzyme Type ID lipase001099
Protein Name Apolipoprotein A-V
Apo-AV
ApoA-V
Apolipoprotein A5
Regeneration-associated protein 3
Gene Name APOA5 RAP3 UNQ411/PRO773
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MASMAAVLTWALALLSAFSATQARKGFWDYFSQTSGDKGRVEQIHQQKMAREPATLKDSLEQDLNNMNKFLEKLRPLSGSEAPRLPQDPVGMRRQLQEELEEVKARLQPYMAEAHELVGWNLEGLRQQLKPYTMDLMEQVALRVQELQEQLRVVGEDTKAQLLGGVDEAWALLQGLQSRVVHHTGRFKELFHPYAESLVSGIGRHVQELHRSVAPHAPASPARLSRCVQVLSRKLTLKAKALHARIQQNLDQLREELSRAFAGTGTEEGAGPDPQMLSEEVRQRLQAFRQDTYLQIAAFTRAIDQETEEVQQQLAPPPPGHSAFAPEFQQTDSGKVLSKLQARLDDLWEDITHSLHDQGHSHLGDP
Enzyme Length 366
Uniprot Accession Number Q6Q788
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin (PubMed:17326667). {ECO:0000250|UniProtKB:Q8C7G5, ECO:0000269|PubMed:11588264, ECO:0000269|PubMed:12899628, ECO:0000269|PubMed:15528295, ECO:0000269|PubMed:17326667}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Coiled coil (2); Erroneous initiation (2); Erroneous termination (1); Modified residue (2); Mutagenesis (1); Natural variant (4); Signal peptide (1)
Keywords Chylomicron;Coiled coil;Disease variant;Endosome;Golgi apparatus;HDL;Lipid transport;Phosphoprotein;Reference proteome;Secreted;Signal;Transport;VLDL
Interact With Q96CM8; O95393; Q96MX0; Q96DZ9-2; Q9NX76; Q8NDC4; Q9HB07; Q9BQE4; A0PK00; Q96HH6; Q9BTV4; P49638; O95070
Induction INDUCTION: Up-regulated by PPARA agonists, which are used clinically to lower serum TG (such as fibrates). {ECO:0000269|PubMed:12709436}.
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12810715}. Early endosome {ECO:0000269|PubMed:18603531}. Late endosome {ECO:0000269|PubMed:18603531}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:18603531}. Note=In the presence of SORL1, internalized to early endosomes, sorted in a retrograde fashion to late endosomes, from which a portion is sent to lysosomes and degradation, another portion is sorted to the trans-Golgi network. {ECO:0000269|PubMed:18603531}.
Modified Residue MOD_RES 55; /note=Phosphothreonine; by FAM20C; /evidence=ECO:0000269|PubMed:26091039; MOD_RES 59; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:24275569
Post Translational Modification PTM: Phosphorylated by FAM20C in the extracellular medium. {ECO:0000269|PubMed:26091039}.
Signal Peptide SIGNAL 1..23; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 12417270; 12417525; 12436249; 12615678; 12637506; 12664082; 12671030; 12676816; 12697303; 12747596; 12752569; 1279089; 12818421; 12937897; 12951359; 14613578; 14729863; 14732475; 14959997; 14984471; 15046561; 15131258; 15135251; 15151505; 15157276; 15177130; 15178420; 15300628; 15306190; 15317819; 15342688; 15369751; 15447887; 15542401; 15591215; 15604515; 15636639; 15649902; 15684402; 15781255; 15790933; 15841042; 15857156; 15877284; 15878877; 15924804; 15941721; 15952115; 15996212; 16006256; 16039297; 16046221; 16051671; 16054149; 16143024; 16192625; 16258166; 16311097; 16321685; 16325772; 16375582; 16386723; 16386743; 16401313; 16410456; 16448983; 16474174; 16531747; 16636175; 16682041; 16687148; 16710093; 16763159; 16769999; 16777114; 16781717; 16806135; 16806226; 16861622; 16887900; 16917759; 16943456; 16954607; 17032446; 17087641; 17142127; 17157483; 17183147; 17197160; 17211608; 17222847; 17356049; 17378725; 17431185; 17457003; 17460328; 17485571; 17493548; 17495607; 17548321; 17548323; 17635078; 17693622; 17700364; 17705673; 17717288; 17722232; 17726453; 17766366; 17768309; 17855807; 17922054; 17922432; 17936576; 17957227; 17964293; 18056685; 18078817; 18087544; 18159097; 18179892; 18193043; 18193044; 18193158; 18206649; 18263854; 18274205; 18274806; 18302531; 18395529; 18424353; 18441017; 18468520; 18537870; 18543217; 18549811; 18572192; 18577813; 18579034; 18596051; 18601597; 18601598; 18607181; 18635818; 18658049; 18660489; 18678879; 18779834; 18789138; 18801202; 18946207; 18974842; 19018513; 19034316; 19055447; 19056482; 19056598; 19057464; 19060906; 19060911; 19074352; 19107359; 19121291; 19141870; 19148283; 19150068; 19159622; 19185284; 19185864; 19187029; 19207029; 19253837; 19336370; 19336475; 19344899; 19362162; 19403283; 19410254; 19447388; 19530961; 19534808; 19567162; 19578796; 19592705; 19629056; 19656773; 19665689; 19692219; 19701693; 19710929; 19732897; 19765959; 19825998; 19828688; 19847674; 19878569; 19910639; 19913121; 19915960; 19932084; 19948975; 20031591; 20047745; 20054229; 20059973; 20134407; 20137539; 20160193; 20170397; 20303129; 20304614; 20331378; 20392444; 20395964; 20400780; 20413122; 20429872; 20430392; 20442857; 20452521; 20469899; 20480398; 20490738; 20571505; 20604726; 20628086; 20634891; 20657596; 20674306; 20679960; 20688329; 20696075; 20708914; 20714348; 20802161; 20855565; 20869952; 20883102; 20966404; 21033077; 21054477; 21130994; 21132386; 21143013; 21209257; 21238903; 21287515; 21324458; 21375366; 21423763; 21438666; 21463987; 21473680; 21489765; 21505768; 21518542; 21548985; 21646779; 21666694; 21707471; 21854571; 21889769; 21914952; 21988832; 21993410; 22008704; 22239554; 22262056; 22350263; 22425169; 22517333; 22576629; 22675253; 22688093; 22718631; 22796346; 22809445; 22905904; 22914552; 22914599; 22924697; 23000161; 23009782; 23065249; 23129316; 23150946; 23248205; 23266809; 23307945; 23312054; 23329134; 23415427; 23452379; 23468858; 23479152; 23499587; 23505323; 23509746; 23656756; 23919616; 23957007; 23970179; 24023260; 24136289; 24161374; 24178511; 24402875; 24462044; 24586566; 24591733; 24618354; 24684850; 24690159; 24694356; 24709297; 24768220; 24775272; 24793350; 24815086; 24886709; 24903888; 25034063; 25073959; 25127531; 25263629; 25308402; 25313938; 25463085; 25515090; 25770687; 25843152; 25900265; 25938357; 26309253; 26350810; 26365620; 26365669; 26387083; 26397108; 26505382; 26524954; 26634697; 26702748; 26760709; 26782469; 26824674; 27051036; 27053630; 27206937; 27350673; 27415775; 27599772; 27613158; 27716220; 27724895; 27813673; 28102463; 28143480; 28371326; 28376804; 28500476; 28534127; 28624160; 28635360; 28730827; 28865324; 28927406; 29263402; 29264753; 29310573; 29398535; 29735301; 29758349; 29797594; 29866721; 30024021; 30053818; 30132804; 30139016; 30367981; 30422238; 30472712; 30600310; 30606120; 30890818; 30902391; 31165758; 31253212; 31560287; 31619059; 31831525; 31903892; 32382544; 32437778; 32561169; 32602585; 32633266; 32725151; 32777089; 33567543; 33753020; 33986338; 34422134; 3942763; 5057882; 8728311;
Motif
Gene Encoded By
Mass 41,213
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda