IED ID |
IndEnz0005001137 |
Enzyme Type ID |
lipase001137 |
Protein Name |
Nuclear hormone receptor family member nhr-76
|
Gene Name |
nhr-76 C05G6.1 |
Organism |
Caenorhabditis elegans |
Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Nematoda (roundworms)
Chromadorea
Rhabditida
Rhabditina
Rhabditomorpha
Rhabditoidea
Rhabditidae
Peloderinae
Caenorhabditis
Caenorhabditis elegans
|
Enzyme Sequence |
MEVLGKQKVLAMMKLNGAGQLTGYPFETPSSSTTTPSVPPSFPHSSNPNAYMKPSPPSAISSPPSTSSCSSASEKKECAVCKNPNSSGYHFGCIACAACSAFFRRTVVLSRRYYCRRDPVGNSLCPLDRRHRSNCRACRYVRCIDMGMNPSSVQNLRDSIKPRSPAEMIQEAEEEDKKEKLDDILFSAATPGSWISSTSTCNEPLPVAPKEIPGENYIETLAALYKNSVERRRMFYCNGSLREMLGGTGLKMRPTRFDERYYKEKMRFELVLYVEMMNSMSVFRQMDLDTKETLVKGCAVSLAMLEKYYISVKYDGLRTQKLIAPDGSYTDLSDHGAQFDDEFTQITESVMDKETCLKLLYDPLRSCLNELGSALEHSRMTDTEFCALFAILLFNTAADNLSDASRNAVVMARNRVMKDWFEFYAKQGIDPHEAGLLVGNTLLLLTAVRNAMAVHRENFHVIRVFNVMEYDKLIDDLAFT |
Enzyme Length |
480 |
Uniprot Accession Number |
Q65CM0 |
Absorption |
|
Active Site |
|
Activity Regulation |
|
Binding Site |
|
Calcium Binding |
|
catalytic Activity |
|
DNA Binding |
DNA_BIND 75..155; /note=Nuclear receptor; /evidence=ECO:0000255|PROSITE-ProRule:PRU00407 |
EC Number |
|
Enzyme Function |
FUNCTION: Ligand-activated transcription factor (By similarity). Involved in modulating serotonin-mediated induction of adipose triglyceride lipase atgl-1, thereby regulating body fat (PubMed:24120942). {ECO:0000250|UniProtKB:P24468, ECO:0000269|PubMed:24120942}. |
Temperature Dependency |
|
PH Dependency |
|
Pathway |
|
nucleotide Binding |
|
Features |
Chain (1); DNA binding (1); Domain (1); Region (1); Zinc finger (2) |
Keywords |
DNA-binding;Metal-binding;Nucleus;Receptor;Reference proteome;Transcription;Transcription regulation;Zinc;Zinc-finger |
Interact With |
O45666 |
Induction |
|
Subcellular Location |
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}. |
Modified Residue |
|
Post Translational Modification |
|
Signal Peptide |
|
Structure 3D |
|
Cross Reference PDB |
- |
Mapped Pubmed ID |
10545240;
10778742;
14704431;
19123269;
20439776;
21177967;
22267497;
22286215;
22511885;
22560298;
22901814;
23791784;
23800452;
24884423;
25487147;
6593563;
|
Motif |
|
Gene Encoded By |
|
Mass |
53,940 |
Kinetics |
|
Metal Binding |
|
Rhea ID |
|
Cross Reference Brenda |
|