| IED ID |
IndEnz0005001137 |
| Enzyme Type ID |
lipase001137 |
| Protein Name |
Nuclear hormone receptor family member nhr-76
|
| Gene Name |
nhr-76 C05G6.1 |
| Organism |
Caenorhabditis elegans |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Nematoda (roundworms)
Chromadorea
Rhabditida
Rhabditina
Rhabditomorpha
Rhabditoidea
Rhabditidae
Peloderinae
Caenorhabditis
Caenorhabditis elegans
|
| Enzyme Sequence |
MEVLGKQKVLAMMKLNGAGQLTGYPFETPSSSTTTPSVPPSFPHSSNPNAYMKPSPPSAISSPPSTSSCSSASEKKECAVCKNPNSSGYHFGCIACAACSAFFRRTVVLSRRYYCRRDPVGNSLCPLDRRHRSNCRACRYVRCIDMGMNPSSVQNLRDSIKPRSPAEMIQEAEEEDKKEKLDDILFSAATPGSWISSTSTCNEPLPVAPKEIPGENYIETLAALYKNSVERRRMFYCNGSLREMLGGTGLKMRPTRFDERYYKEKMRFELVLYVEMMNSMSVFRQMDLDTKETLVKGCAVSLAMLEKYYISVKYDGLRTQKLIAPDGSYTDLSDHGAQFDDEFTQITESVMDKETCLKLLYDPLRSCLNELGSALEHSRMTDTEFCALFAILLFNTAADNLSDASRNAVVMARNRVMKDWFEFYAKQGIDPHEAGLLVGNTLLLLTAVRNAMAVHRENFHVIRVFNVMEYDKLIDDLAFT |
| Enzyme Length |
480 |
| Uniprot Accession Number |
Q65CM0 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
DNA_BIND 75..155; /note=Nuclear receptor; /evidence=ECO:0000255|PROSITE-ProRule:PRU00407 |
| EC Number |
|
| Enzyme Function |
FUNCTION: Ligand-activated transcription factor (By similarity). Involved in modulating serotonin-mediated induction of adipose triglyceride lipase atgl-1, thereby regulating body fat (PubMed:24120942). {ECO:0000250|UniProtKB:P24468, ECO:0000269|PubMed:24120942}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); DNA binding (1); Domain (1); Region (1); Zinc finger (2) |
| Keywords |
DNA-binding;Metal-binding;Nucleus;Receptor;Reference proteome;Transcription;Transcription regulation;Zinc;Zinc-finger |
| Interact With |
O45666 |
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
|
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
10545240;
10778742;
14704431;
19123269;
20439776;
21177967;
22267497;
22286215;
22511885;
22560298;
22901814;
23791784;
23800452;
24884423;
25487147;
6593563;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
53,940 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|