Detail Information for IndEnz0005001155
IED ID IndEnz0005001155
Enzyme Type ID lipase001155
Protein Name Colipase
Gene Name CLPS
Organism Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Sciuromorpha (squirrels) Sciuridae Xerinae Marmotini Ictidomys (lined ground squirrels) Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus)
Enzyme Sequence MKVLVLLLVTLAVVYAAPDPRGILINLEDGEICMNSAQCKSSCCQHFSPLGVARCTRKASENSECSPKTLYGIYYKCPCERGLTCESDRTIIGAITNTNYGICLDAGRSKE
Enzyme Length 111
Uniprot Accession Number Q91XL7
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. {ECO:0000250|UniProtKB:P04118}.; FUNCTION: Enterostatin has a biological activity as a satiety signal. {ECO:0000250|UniProtKB:P04118}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Disulfide bond (5); Propeptide (1); Signal peptide (1)
Keywords Digestion;Disulfide bond;Lipid degradation;Lipid metabolism;Reference proteome;Secreted;Signal
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..16; /evidence=ECO:0000250
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 12,056
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda