| IED ID | IndEnz0005001181 |
| Enzyme Type ID | lipase001181 |
| Protein Name |
Beta-2-glycoprotein 1 APC inhibitor Activated protein C-binding protein Anticardiolipin cofactor Apolipoprotein H Apo-H Beta-2-glycoprotein I B2GPI Beta 2 GPI |
| Gene Name | APOH B2G1 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MISPVLILFSSFLCHVAIAGRTCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAMPSCKASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFCKNKEKKCSYTEDAQCIDGTIEVPKCFKEHSSLAFWKTDASDVKPC |
| Enzyme Length | 345 |
| Uniprot Accession Number | P02749 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (32); Chain (1); Disulfide bond (11); Domain (4); Glycosylation (6); Helix (2); Natural variant (6); Region (1); Sequence conflict (2); Signal peptide (1); Turn (3) |
| Keywords | 3D-structure;Direct protein sequencing;Disulfide bond;Glycoprotein;Heparin-binding;Reference proteome;Repeat;Secreted;Signal;Sushi |
| Interact With | Itself; P13473-2; P01130; P08519; P11226; P02776; P00747; Q9Y371; Q924X6; Itself; P02776 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | PTM: N- and O-glycosylated. PubMed:6587378 also reports glycosylation on 'Asn-188' for their allele. {ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:6587378}. |
| Signal Peptide | SIGNAL 1..19; /evidence="ECO:0000269|PubMed:11250549, ECO:0000269|PubMed:1602135, ECO:0000269|PubMed:2349221, ECO:0000269|PubMed:6587378" |
| Structure 3D | X-ray crystallography (11); NMR spectroscopy (3) |
| Cross Reference PDB | 1C1Z; 1G4F; 1G4G; 1QUB; 2KRI; 3OP8; 4JHS; 6V06; 6V08; 6V09; 6XSD; 6XST; 7JIK; 7KG4; |
| Mapped Pubmed ID | 11124037; 11434778; 11686326; 11816715; 11953211; 12031135; 12038453; 12124280; 12139935; 12235181; 12362233; 12371681; 12428105; 12440522; 12441378; 12471146; 12495080; 12495081; 12562869; 12571857; 12590955; 12605674; 12648080; 12673579; 12807892; 12887738; 12918732; 1435334; 14601646; 14644075; 14707422; 14719180; 14726399; 14768953; 15025925; 15094940; 15252864; 15486070; 15488942; 15507263; 15507264; 15522884; 15534879; 15641049; 15653437; 15821830; 15916797; 15956288; 16038107; 16159595; 16480936; 16625500; 16686261; 16724168; 16855163; 16879209; 16905548; 16938165; 16960938; 17053060; 17057945; 17096706; 17200780; 17469158; 17603016; 17626983; 17662972; 17715943; 17726161; 17872974; 18029906; 18034767; 18093092; 18205270; 18328538; 18383370; 18452581; 18495556; 18521522; 18624398; 18676959; 18695102; 18777117; 18822289; 18996102; 19002041; 19052923; 19069167; 19132787; 19248095; 19275896; 19350132; 19578796; 19676115; 19694946; 19706343; 19706887; 19758193; 19805618; 19851667; 19878946; 19913121; 19965629; 20004024; 20026018; 20029801; 20089041; 20140737; 20204408; 20223219; 20237496; 20440842; 20539917; 20581778; 20601596; 20602615; 20628086; 20629942; 20665665; 20874780; 20979592; 21179511; 21240499; 21478209; 21498672; 21501325; 21535391; 21602492; 21618459; 21899894; 21999151; 22056596; 22246055; 22358146; 22394675; 22399073; 22427365; 22635228; 22635233; 22940059; 22956423; 22964479; 23214196; 23279374; 23467542; 23578283; 23692565; 23954892; 24120690; 24136289; 24275099; 24315780; 24472415; 24661363; 24685231; 24905490; 25071084; 25081279; 25256745; 25405208; 25556540; 26045739; 26261630; 26670100; 26711810; 26900811; 27030319; 27063992; 27140515; 27770664; 28079888; 28363116; 28667788; 28731130; 28811580; 29350259; 30074200; 30442725; 30626470; 31134087; 32368987; 32518155; 32896248; 32938215; 33115273; 33355374; 33370716; 33641242; 34197876; 9269765; |
| Motif | |
| Gene Encoded By | |
| Mass | 38,298 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |