| IED ID | IndEnz0005001233 |
| Enzyme Type ID | lipase001233 |
| Protein Name |
Apolipoprotein C-II Apo-CII ApoC-II Apolipoprotein C2 Cleaved into: Proapolipoprotein C-II ProapoC-II |
| Gene Name | APOC2 |
| Organism | Tapirus indicus (Asiatic tapir) (Malayan tapir) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Perissodactyla (odd-toed ungulates) Tapiridae (tapirs) Tapirus Tapirus indicus (Asiatic tapir) (Malayan tapir) |
| Enzyme Sequence | MGARHLLALLLVLLVLGFEVQGAQVPQQDEAANTTLLTQVQESLLSYWDSTKAAAQDLYKKTYLTTMDEKIRDMFSKSTAAVSTYVGIFTDQLLSLLKGDE |
| Enzyme Length | 101 |
| Uniprot Accession Number | P0DUP3 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. {ECO:0000250|UniProtKB:P02655}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (2); Region (2); Signal peptide (1) |
| Keywords | Chylomicron;Glycoprotein;HDL;LDL;Lipid degradation;Lipid metabolism;Lipid transport;Secreted;Sialic acid;Signal;Transport;VLDL |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02655}. |
| Modified Residue | |
| Post Translational Modification | PTM: Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing. {ECO:0000250|UniProtKB:P02655}.; PTM: Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma. {ECO:0000250|UniProtKB:P02655}. |
| Signal Peptide | SIGNAL 1..22; /evidence=ECO:0000250|UniProtKB:P18658 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 11,172 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |