| IED ID | IndEnz0005001251 |
| Enzyme Type ID | lipase001251 |
| Protein Name |
Rab GDP dissociation inhibitor beta Rab GDI beta Guanosine diphosphate dissociation inhibitor 2 GDI-2 |
| Gene Name | GDI2 RABGDIB |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MNEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESASITPLEDLYKRFKIPGSPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDFKVTEGSFVYKGGKIYKVPSTEAEALASSLMGLFEKRRFRKFLVYVANFDEKDPRTFEGIDPKKTTMRDVYKKFDLGQDVIDFTGHALALYRTDDYLDQPCYETINRIKLYSESLARYGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPIEEIIVQNGKVIGVKSEGEIARCKQLICDPSYVKDRVEKVGQVIRVICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISFAHNVAAQGKYIAIVSTTVETKEPEKEIRPALELLEPIEQKFVSISDLLVPKDLGTESQIFISRTYDATTHFETTCDDIKNIYKRMTGSEFDFEEMKRKKNDIYGED |
| Enzyme Length | 445 |
| Uniprot Accession Number | P50395 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking (PubMed:25860027). Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A (PubMed:25860027). {ECO:0000269|PubMed:25860027}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (1); Chain (1); Modified residue (7); Sequence conflict (1) |
| Keywords | Acetylation;Alternative splicing;Cytoplasm;GTPase activation;Membrane;Phosphoprotein;Reference proteome |
| Interact With | P62820-1; Q8BMD2; Q8BMD2-1; P61027; P55258; P61007 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. |
| Modified Residue | MOD_RES 1; /note="N-acetylmethionine"; /evidence="ECO:0007744|PubMed:19413330"; MOD_RES 57; /note="N6-succinyllysine"; /evidence="ECO:0000250|UniProtKB:Q61598"; MOD_RES 61; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163"; MOD_RES 112; /note="N6-acetyllysine"; /evidence="ECO:0007744|PubMed:19608861"; MOD_RES 130; /note="Phosphoserine"; /evidence="ECO:0000250|UniProtKB:P50399"; MOD_RES 269; /note="N6-acetyllysine"; /evidence="ECO:0007744|PubMed:19608861"; MOD_RES 382; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:24275569" |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10818110; 10990452; 11038176; 11179213; 11516400; 11689439; 11703925; 11746448; 11771757; 11784320; 11917121; 12058051; 12221131; 12244319; 12364329; 12427552; 12475894; 12684051; 12944476; 12972505; 15096524; 15138286; 1516130; 15247254; 15388334; 15528189; 15561770; 15692570; 15878329; 15914536; 15958533; 16207721; 16373702; 16385451; 16410077; 16525024; 16525121; 16571673; 16641372; 16754960; 16880209; 16950109; 17043139; 17132146; 17189207; 17208202; 17239822; 17287728; 17353931; 17488286; 17507299; 17562788; 17574030; 17646400; 17671165; 17678623; 18076383; 18094055; 18354496; 18367545; 1845915; 18477474; 18559336; 18585354; 18664496; 18701652; 18779367; 18804435; 1900457; 19109890; 19135240; 19345684; 19403694; 19490898; 19570034; 19620288; 19656848; 19725050; 19729655; 19738201; 19745841; 20008558; 20154091; 20159109; 20159556; 20305638; 20308558; 20360068; 20404108; 20434987; 20562859; 20592283; 20711500; 20797862; 20851765; 20937701; 21041651; 2115402; 21183348; 21187289; 21216617; 21273506; 21330364; 21421921; 21445324; 21458671; 21532587; 21554507; 21565611; 21586568; 21683469; 21706022; 21718402; 21776405; 21951725; 21988832; 22013193; 22065758; 22072793; 22171327; 22252131; 22365832; 22433857; 22511774; 22581368; 22595670; 22622570; 22648168; 22653444; 22705394; 22762500; 22810585; 22908308; 22983554; 23084991; 23091056; 23176487; 23176493; 23220125; 23239882; 23247405; 23263280; 23333653; 23351085; 23357852; 23378591; 23416715; 23420520; 23444368; 23478338; 23645161; 23650620; 23678941; 23684622; 23713133; 23839779; 24284321; 24296415; 24366813; 24644286; 24694596; 24719330; 24891604; 24917561; 24967941; 25074980; 25277244; 25341920; 25343031; 25472813; 25609649; 25648148; 25713415; 25925668; 26177209; 26245486; 26434594; 26496610; 26538022; 26925400; 26936971; 27041585; 27044746; 27103185; 27246931; 27329675; 32945458; 34051575; 34556814; 7688123; 7911226; 8144603; 8408203; 8522602; 8692836; 8863739; 9020086; 9020161; 9030515; 9136770; 9323142; 9590177; 9733780; |
| Motif | |
| Gene Encoded By | |
| Mass | 50,663 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |