Detail Information for IndEnz0005001419
IED ID IndEnz0005001419
Enzyme Type ID lipase001419
Protein Name Apolipoprotein A-IV
Apo-AIV
ApoA-IV
Apolipoprotein A4
Gene Name APOA4
Organism Canis lupus familiaris (Dog) (Canis familiaris)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Carnivora Caniformia Canidae (dog coyote wolf fox) Canis Canis lupus (Gray wolf) Canis lupus familiaris (Dog) (Canis familiaris)
Enzyme Sequence MFLKAVVLTLSLVAITGARAEVSADQVATVVWDYFSQLSNNAKEAVEHLQQSELTQQLKSVTKGHISALRVIEKGRERNSWEHSRRVGPCEIMGRQVGIFGQPLRVATLPNCDLPVNSVPPNTHLSQAVGPYAEELRTQVNTHAEQLRNQLTSHAQRMQSALRQNVDDLHSSLTPFADELKAKIDQNVEELKGHLTPYTDELKVKIDQNVEELRRSLAPYAQDVQEKLNHQLEGLAFQMKKNAEELKAKISANAEELRQRLAPVAEDVRGKLKDNTAGLHKSLAELSSRLDQQVEEFRRNVGPYGETFNKALLQQVEELRQKLGPYAGDMEDHLSFLEKDLRDKVNSFFSTLQEKESQDTPVALPKQEQEQSAVPLES
Enzyme Length 378
Uniprot Accession Number E2RE76
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons. {ECO:0000250|UniProtKB:P06727}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Region (2); Repeat (13); Signal peptide (1)
Keywords Chylomicron;HDL;Lipid transport;Reference proteome;Repeat;Secreted;Signal;Transport
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P06727}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..20; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 42,536
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda