Detail Information for IndEnz0005001422
IED ID IndEnz0005001422
Enzyme Type ID lipase001422
Protein Name Apolipoprotein A-IV
Apo-AIV
ApoA-IV
Apolipoprotein A4
Gene Name APOA4
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MFLKAVVLTLALVAVAGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQMLAPLES
Enzyme Length 396
Uniprot Accession Number P06727
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Beta strand (1); Chain (1); Compositional bias (1); Helix (7); Natural variant (17); Region (2); Repeat (13); Sequence conflict (4); Signal peptide (1)
Keywords 3D-structure;Chylomicron;HDL;Lipid transport;Phosphoprotein;Reference proteome;Repeat;Secreted;Signal;Transport
Interact With Q6RW13-2; Itself; P55212; Q8IZR5-2; Q96DZ9-2; P43360; P20393; Q9Y371
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted.
Modified Residue
Post Translational Modification PTM: Phosphorylation sites are present in the extracellular medium.
Signal Peptide SIGNAL 1..20; /evidence=ECO:0000269|PubMed:6706947
Structure 3D X-ray crystallography (1)
Cross Reference PDB 3S84;
Mapped Pubmed ID 10391242; 10411933; 10428310; 10559562; 10583407; 10951531; 11060341; 11108737; 11181750; 11181758; 11401442; 11467836; 11472750; 11583715; 11592042; 11841825; 118839; 11940599; 11941585; 11952809; 12082592; 12116231; 12121350; 12220435; 12417525; 12495081; 12518019; 12556235; 12664082; 12676816; 12691171; 12692552; 12697303; 1270801; 12777472; 1279089; 12860258; 12962772; 14732096; 14751811; 15174051; 15175360; 15252864; 15254593; 15258202; 15304365; 15359534; 15488874; 15559160; 15583000; 15649902; 15721024; 15764642; 15806598; 15823278; 15864114; 15868628; 15910632; 15928313; 15962178; 15962837; 16030523; 16105043; 16120654; 16159879; 16200213; 16321685; 16326171; 16338932; 16602826; 16651467; 16710093; 16763159; 16770585; 16781717; 16788210; 16945374; 17130180; 17206692; 17261136; 17378725; 17457002; 17644776; 17654446; 17712726; 17825930; 17855807; 17964293; 18193043; 18193044; 1837051; 18430727; 18449172; 18484335; 1849145; 18507396; 18513389; 1856611; 18636124; 18660489; 18664021; 18676680; 18678879; 18789138; 18948973; 18996102; 19057464; 19060906; 19060911; 19074352; 19131662; 19166692; 19170196; 19263529; 19336370; 19336475; 19403283; 19433068; 19592705; 19625176; 19689828; 19692168; 19701693; 19732897; 19878569; 19913121; 19948975; 20031551; 20117098; 20164363; 20430392; 20554794; 20602615; 20609189; 20628086; 20674306; 20714348; 20807650; 20810159; 21127258; 2118650; 21297956; 21324458; 21407247; 21666694; 21767760; 2195544; 22262056; 23096082; 23132909; 23288849; 23300094; 23338533; 2409350; 24211975; 24311788; 24425874; 24598141; 24606699; 25463085; 25733664; 26397108; 26485402; 26491253; 26556724; 27262366; 27344311; 27412012; 27622441; 27870653; 2793848; 279930; 28246167; 2900981; 29025558; 29317355; 30190457; 3035556; 3053705; 3080684; 3094007; 3142462; 32388438; 32410861; 32437778; 32921312; 33130088; 33544467; 33640722; 34185819; 34394117; 3942763; 4345202; 5057882; 7683668; 7958503; 8097946; 8159701; 8464497; 8490014; 8536954; 8728311; 8870004; 9006323; 9054935; 9862427; 9925661;
Motif
Gene Encoded By
Mass 45,372
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda