| IED ID | IndEnz0005001422 |
| Enzyme Type ID | lipase001422 |
| Protein Name |
Apolipoprotein A-IV Apo-AIV ApoA-IV Apolipoprotein A4 |
| Gene Name | APOA4 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MFLKAVVLTLALVAVAGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQMLAPLES |
| Enzyme Length | 396 |
| Uniprot Accession Number | P06727 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (1); Chain (1); Compositional bias (1); Helix (7); Natural variant (17); Region (2); Repeat (13); Sequence conflict (4); Signal peptide (1) |
| Keywords | 3D-structure;Chylomicron;HDL;Lipid transport;Phosphoprotein;Reference proteome;Repeat;Secreted;Signal;Transport |
| Interact With | Q6RW13-2; Itself; P55212; Q8IZR5-2; Q96DZ9-2; P43360; P20393; Q9Y371 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | PTM: Phosphorylation sites are present in the extracellular medium. |
| Signal Peptide | SIGNAL 1..20; /evidence=ECO:0000269|PubMed:6706947 |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 3S84; |
| Mapped Pubmed ID | 10391242; 10411933; 10428310; 10559562; 10583407; 10951531; 11060341; 11108737; 11181750; 11181758; 11401442; 11467836; 11472750; 11583715; 11592042; 11841825; 118839; 11940599; 11941585; 11952809; 12082592; 12116231; 12121350; 12220435; 12417525; 12495081; 12518019; 12556235; 12664082; 12676816; 12691171; 12692552; 12697303; 1270801; 12777472; 1279089; 12860258; 12962772; 14732096; 14751811; 15174051; 15175360; 15252864; 15254593; 15258202; 15304365; 15359534; 15488874; 15559160; 15583000; 15649902; 15721024; 15764642; 15806598; 15823278; 15864114; 15868628; 15910632; 15928313; 15962178; 15962837; 16030523; 16105043; 16120654; 16159879; 16200213; 16321685; 16326171; 16338932; 16602826; 16651467; 16710093; 16763159; 16770585; 16781717; 16788210; 16945374; 17130180; 17206692; 17261136; 17378725; 17457002; 17644776; 17654446; 17712726; 17825930; 17855807; 17964293; 18193043; 18193044; 1837051; 18430727; 18449172; 18484335; 1849145; 18507396; 18513389; 1856611; 18636124; 18660489; 18664021; 18676680; 18678879; 18789138; 18948973; 18996102; 19057464; 19060906; 19060911; 19074352; 19131662; 19166692; 19170196; 19263529; 19336370; 19336475; 19403283; 19433068; 19592705; 19625176; 19689828; 19692168; 19701693; 19732897; 19878569; 19913121; 19948975; 20031551; 20117098; 20164363; 20430392; 20554794; 20602615; 20609189; 20628086; 20674306; 20714348; 20807650; 20810159; 21127258; 2118650; 21297956; 21324458; 21407247; 21666694; 21767760; 2195544; 22262056; 23096082; 23132909; 23288849; 23300094; 23338533; 2409350; 24211975; 24311788; 24425874; 24598141; 24606699; 25463085; 25733664; 26397108; 26485402; 26491253; 26556724; 27262366; 27344311; 27412012; 27622441; 27870653; 2793848; 279930; 28246167; 2900981; 29025558; 29317355; 30190457; 3035556; 3053705; 3080684; 3094007; 3142462; 32388438; 32410861; 32437778; 32921312; 33130088; 33544467; 33640722; 34185819; 34394117; 3942763; 4345202; 5057882; 7683668; 7958503; 8097946; 8159701; 8464497; 8490014; 8536954; 8728311; 8870004; 9006323; 9054935; 9862427; 9925661; |
| Motif | |
| Gene Encoded By | |
| Mass | 45,372 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |