| IED ID | IndEnz0005001427 |
| Enzyme Type ID | lipase001427 |
| Protein Name |
Apolipoprotein A-I Apo-AI ApoA-I Apolipoprotein A1 Cleaved into: Proapolipoprotein A-I ProapoA-I |
| Gene Name | APOA1 |
| Organism | Gallus gallus (Chicken) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Archelosauria Archosauria Dinosauria Saurischia Theropoda Coelurosauria Aves Neognathae Galloanserae Galliformes Phasianidae (turkeys) Phasianinae Gallus Gallus gallus (Chicken) |
| Enzyme Sequence | MRGVLVTLAVLFLTGTQARSFWQHDEPQTPLDRIRDMVDVYLETVKASGKDAIAQFESSAVGKQLDLKLADNLDTLSAAAAKLREDMAPYYKEVREMWLKDTEALRAELTKDLEEVKEKIRPFLDQFSAKWTEELEQYRQRLTPVAQELKELTKQKVELMQAKLTPVAEEARDRLRGHVEELRKNLAPYSDELRQKLSQKLEEIREKGIPQASEYQAKVMEQLSNLREKMTPLVQEFRERLTPYAENLKNRLISFLDELQKSVA |
| Enzyme Length | 264 |
| Uniprot Accession Number | P08250 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (2); Region (1); Repeat (10); Sequence conflict (3); Signal peptide (1) |
| Keywords | Cholesterol metabolism;Direct protein sequencing;HDL;Lipid metabolism;Lipid transport;Reference proteome;Repeat;Secreted;Signal;Steroid metabolism;Sterol metabolism;Transport |
| Interact With | Q9KH15 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..18 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 15749000; 16921168; 18672094; 22174833; 26549235; 27402828; 28938763; 30932484; |
| Motif | |
| Gene Encoded By | |
| Mass | 30,680 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |