Detail Information for IndEnz0005001458
IED ID IndEnz0005001458
Enzyme Type ID lipase001458
Protein Name Apolipoprotein C-III
Apo-CIII
ApoC-III
Apolipoprotein C3
Gene Name APOC3
Organism Equus caballus (Horse)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Perissodactyla (odd-toed ungulates) Equidae (horses) Equus Equus Equus caballus (Horse)
Enzyme Sequence MQPRVLLIAALLALLATAAEDKDASLLDVVQGYMQQASKTAKDTLTSMQESQVAQQARDWVNDGLSSLKDYWGKLKGKFSSFWDSTFEDTTPSPAVA
Enzyme Length 97
Uniprot Accession Number P0DN28
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners. {ECO:0000250|UniProtKB:P02656}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Region (1); Signal peptide (1); Site (1)
Keywords Chylomicron;Glycoprotein;Lipid degradation;Lipid metabolism;Lipid transport;Reference proteome;Secreted;Sialic acid;Signal;Transport;VLDL
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02656}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..18; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 10,598
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda