IED Industry Enzyme Database

Detail Information for IndEnz0007000017
IED ID IndEnz0007000017
Enzyme Type ID catalase000017
Protein Name Catalase
EC 1.11.1.6
Gene Name Cat Cas-1 Cas1
Organism Mus musculus (Mouse)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse)
Enzyme Sequence MSDSRDPASDQMKQWKEQRASQRPDVLTTGGGNPIGDKLNIMTAGSRGPLLVQDVVFTDEMAHFDRERIPERVVHAKGAGAFGYFEVTHDITRYSKAKVFEHIGKRTPIAVRFSTVTGESGSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDAILFPSFIHSQKRNPQTHLKDPDMVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNADGEAVYCKFHYKTDQGIKNLPVGEAGRLAQEDPDYGLRDLFNAIANGNYPSWTFYIQVMTFKEAETFPFNPFDLTKVWPHKDYPLIPVGKLVLNKNPVNYFAEVEQMAFDPSNMPPGIEPSPDKMLQGRLFAYPDTHRHRLGPNYLQIPVNCPYRARVANYQRDGPMCMHDNQGGAPNYYPNSFSAPEQQRSALEHSVQCAVDVKRFNSANEDNVTQVRTFYTKVLNEEERKRLCENIAGHLKDAQLFIQKKAVKNFTDVHPDYGARIQALLDKYNAEKPKNAIHTYTQAGSHMAAKGKANL
Enzyme Length 527
Uniprot Accession Number P24270
Absorption
Active Site ACT_SITE 75; /evidence=ECO:0000255|PROSITE-ProRule:PRU10013; ACT_SITE 148; /evidence=ECO:0000255|PROSITE-ProRule:PRU10013
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=2 H2O2 = 2 H2O + O2; Xref=Rhea:RHEA:20309, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240; EC=1.11.1.6; Evidence={ECO:0000255|PROSITE-ProRule:PRU10013};
DNA Binding
EC Number 1.11.1.6
Enzyme Function FUNCTION: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (2); Chain (1); Compositional bias (1); Initiator methionine (1); Metal binding (1); Modified residue (21); Mutagenesis (1); Region (1); Sequence conflict (7)
Keywords Acetylation;Direct protein sequencing;Heme;Hydrogen peroxide;Iron;Metal-binding;Mitogen;NADP;Oxidoreductase;Peroxidase;Peroxisome;Phosphoprotein;Reference proteome
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Peroxisome.
Modified Residue MOD_RES 2; /note="N-acetylserine"; /evidence="ECO:0000269|Ref.8, ECO:0007744|PubMed:23806337"; MOD_RES 9; /note="Phosphoserine"; /evidence="ECO:0000250|UniProtKB:P04040"; MOD_RES 13; /note="N6-succinyllysine"; /evidence="ECO:0007744|PubMed:23806337"; MOD_RES 21; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:17208939, ECO:0007744|PubMed:21183079"; MOD_RES 221; /note="N6-succinyllysine"; /evidence="ECO:0007744|PubMed:23806337"; MOD_RES 233; /note="N6-acetyllysine"; /evidence="ECO:0007744|PubMed:23576753"; MOD_RES 306; /note="N6-acetyllysine; alternate"; /evidence="ECO:0007744|PubMed:23576753"; MOD_RES 306; /note="N6-succinyllysine; alternate"; /evidence="ECO:0007744|PubMed:23806337"; MOD_RES 417; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:17242355"; MOD_RES 422; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:17208939"; MOD_RES 430; /note="N6-acetyllysine; alternate"; /evidence="ECO:0007744|PubMed:23576753"; MOD_RES 430; /note="N6-succinyllysine; alternate"; /evidence="ECO:0007744|PubMed:23806337"; MOD_RES 434; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:21183079"; MOD_RES 449; /note="N6-acetyllysine; alternate"; /evidence="ECO:0007744|PubMed:23576753, ECO:0007744|PubMed:23806337"; MOD_RES 449; /note="N6-succinyllysine; alternate"; /evidence="ECO:0007744|PubMed:23806337"; MOD_RES 480; /note="N6-acetyllysine; alternate"; /evidence="ECO:0007744|PubMed:23576753"; MOD_RES 480; /note="N6-succinyllysine; alternate"; /evidence="ECO:0007744|PubMed:23806337"; MOD_RES 499; /note="N6-acetyllysine"; /evidence="ECO:0007744|PubMed:23576753"; MOD_RES 511; /note="Phosphothreonine"; /evidence="ECO:0000250|UniProtKB:P04040"; MOD_RES 517; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:17208939, ECO:0007744|PubMed:21183079"; MOD_RES 522; /note="N6-succinyllysine"; /evidence="ECO:0007744|PubMed:23806337"
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 10421798; 10524763; 10594242; 10617683; 10645956; 11156684; 11507212; 11779637; 11792727; 11821648; 11829486; 12466851; 12517675; 12521604; 12646716; 12659863; 12915479; 12950161; 1313808; 13782; 14572898; 14586000; 14651853; 14681479; 14710363; 14722014; 15020231; 15026142; 1507224; 15178682; 15317809; 15454285; 15629866; 15637642; 15855331; 16085363; 16105032; 16109828; 16274876; 16445905; 16520238; 16938317; 17045502; 17102991; 17186497; 17250874; 17275685; 17339480; 1735560; 17881773; 17935202; 18073138; 18171680; 18385447; 18718525; 1883320; 19151196; 19293779; 19466610; 19655411; 19690612; 1970329; 19969073; 20237455; 20391537; 20398658; 20456298; 2090377; 20937379; 20971939; 21129156; 21252394; 21295602; 21347610; 21457746; 21460186; 21478259; 21605372; 2173141; 21942371; 21954064; 22030957; 2222810; 22315314; 22733796; 22902401; 22925884; 23085393; 23204527; 23241403; 23360182; 23461683; 2347591; 23624931; 23733920; 23872112; 23911407; 2422116; 24338129; 2443580; 24565075; 24743300; 24786329; 24812425; 24993069; 25131634; 25659933; 25811370; 25975898; 26017143; 26074427; 26456065; 26816051; 27061426; 27133129; 27160095; 27221506; 27363720; 27465136; 27607467; 27614223; 27840320; 27848965; 27939935; 27998725; 28069738; 28117; 28485891; 28629836; 28643395; 28645653; 29097213; 29402993; 30617744; 30658097; 30737259; 30818059; 30938680; 3146546; 31646444; 32152094; 32266253; 32335291; 3244799; 32783660; 32868797; 33080438; 33496364; 3436524; 34390780; 34559475; 4436533; 4666756; 4713148; 4818266; 4975476; 5087482; 5462766; 5703376; 5929246; 6058079; 642030; 6952244; 6961423; 7551822; 7578676; 7698742; 7698761; 7835084; 8000136; 8020965; 8034307; 8153151; 8530024; 8639268; 8720919; 8792216; 8813054; 8903730; 9192846; 9216662; 9545490; 9600348; 9616220;
Motif
Gene Encoded By
Mass 59,795
Kinetics
Metal Binding METAL 358; /note=Iron (heme axial ligand); /evidence=ECO:0000250
Rhea ID RHEA:20309
Cross Reference Brenda