| IED ID | IndEnz0007000022 |
| Enzyme Type ID | catalase000022 |
| Protein Name |
Catalase-2 EC 1.11.1.6 |
| Gene Name | CAT2 CAT At4g35090 M4E13.140 |
| Organism | Arabidopsis thaliana (Mouse-ear cress) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress) |
| Enzyme Sequence | MDPYKYRPASSYNSPFFTTNSGAPVWNNNSSMTVGPRGPILLEDYHLVEKLANFDRERIPERVVHARGASAKGFFEVTHDISNLTCADFLRAPGVQTPVIVRFSTVIHERGSPETLRDPRGFAVKFYTREGNFDLVGNNFPVFFIRDGMKFPDMVHALKPNPKSHIQENWRILDFFSHHPESLNMFTFLFDDIGIPQDYRHMDGSGVNTYMLINKAGKAHYVKFHWKPTCGVKSLLEEDAIRVGGTNHSHATQDLYDSIAAGNYPEWKLFIQIIDPADEDKFDFDPLDVTKTWPEDILPLQPVGRMVLNKNIDNFFAENEQLAFCPAIIVPGIHYSDDKLLQTRVFSYADTQRHRLGPNYLQLPVNAPKCAHHNNHHEGFMNFMHRDEEVNYFPSRYDQVRHAEKYPTPPAVCSGKRERCIIEKENNFKEPGERYRTFTPERQERFIQRWIDALSDPRITHEIRSIWISYWSQADKSLGQKLASRLNVRPSI |
| Enzyme Length | 492 |
| Uniprot Accession Number | P25819 |
| Absorption | |
| Active Site | ACT_SITE 65; /evidence=ECO:0000255|PROSITE-ProRule:PRU10013; ACT_SITE 138; /evidence=ECO:0000255|PROSITE-ProRule:PRU10013 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=2 H2O2 = 2 H2O + O2; Xref=Rhea:RHEA:20309, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240; EC=1.11.1.6; Evidence={ECO:0000255|PROSITE-ProRule:PRU10013}; |
| DNA Binding | |
| EC Number | 1.11.1.6 |
| Enzyme Function | FUNCTION: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Metal binding (1); Natural variant (1); Sequence conflict (4) |
| Keywords | Alternative splicing;Cytoplasm;Glyoxysome;Heme;Hydrogen peroxide;Iron;Metal-binding;Oxidoreductase;Peroxidase;Peroxisome;Reference proteome |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25700484}. Peroxisome {ECO:0000269|PubMed:25700484}. Glyoxysome. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11448761; 14671022; 15028209; 15200641; 15821981; 16336779; 16891552; 16923014; 17080932; 17728292; 17785451; 17877712; 17931347; 18230142; 18775970; 19000166; 19017119; 19149885; 19284649; 19452453; 19825619; 20018591; 20452979; 20484024; 20488891; 20492555; 20530195; 20807338; 20807372; 20876333; 21166475; 21220338; 21631535; 21706351; 21979081; 21985584; 22321773; 22525681; 22771435; 23116669; 23148658; 23210597; 23281391; 23480471; 23689258; 23738953; 23851193; 23940555; 24088017; 24285797; 24299221; 24706550; 24709150; 25928219; 26012558; 26263174; 26317137; 26493993; 26826725; 27225899; 27432873; 27734290; 28107453; 28182949; 28381499; 28622438; 28627464; 28722222; 28869112; 29061866; 29424932; 29575603; 29576081; 30291629; 30409429; 31121523; 31548265; 31702837; 32093294; 32484317; 32564178; 32595686; 32859078; 32887516; 32900442; 33159788; 33199020; 8668130; 8819328; 9212468; 9214587; 9584109; 9836741; |
| Motif | |
| Gene Encoded By | |
| Mass | 56,931 |
| Kinetics | |
| Metal Binding | METAL 348; /note=Iron (heme axial ligand); /evidence=ECO:0000250 |
| Rhea ID | RHEA:20309 |
| Cross Reference Brenda |