| IED ID |
IndEnz0007000023 |
| Enzyme Type ID |
catalase000023 |
| Protein Name |
Catalase
EC 1.11.1.6
|
| Gene Name |
Cat CG6871 |
| Organism |
Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Panarthropoda
Arthropoda
Mandibulata
Pancrustacea
Hexapoda
Insecta
Dicondylia
Pterygota (winged insects)
Neoptera
Endopterygota
Diptera
Brachycera
Muscomorpha
Eremoneura
Cyclorrhapha
Schizophora
Acalyptratae
Ephydroidea
Drosophilidae (pomace flies)
Drosophilinae
Drosophilini
Drosophila (fruit flies)
Sophophora
melanogaster group
melanogaster subgroup
Drosophila melanogaster (Fruit fly)
|
| Enzyme Sequence |
MAGRDAASNQLIDYKNSQTVSPGAITTGNGAPIGIKDASQTVGPRGPILLQDVNFLDEMSHFDRERIPERVVHAKGAGAFGYFEVTHDITQYCAAKIFDKVKKRTPLAVRFSTVGGESGSADTARDPRGFAVKFYTEDGVWDLVGNNTPVFFIRDPILFPSFIHTQKRNPQTHLKDPDMFWDFLTLRPESAHQVCILFSDRGTPDGYCHMNGYGSHTFKLINAKGEPIYAKFHFKTDQGIKNLDVKTADQLASTDPDYSIRDLYNRIKTCKFPSWTMYIQVMTYEQAKKFKYNPFDVTKVWSQKEYPLIPVGKMVLDRNPKNYFAEVEQIAFSPAHLVPGVEPSPDKMLHGRLFSYSDTHRHRLGPNYLQIPVNCPYKVKIENFQRDGAMNVTDNQDGAPNYFPNSFNGPQECPRARALSSCCPVTGDVYRYSSGDTEDNFGQVTDFWVHVLDKCAKKRLVQNIAGHLSNASQFLQERAVKNFTQVHADFGRMLTEELNLAKSSKF |
| Enzyme Length |
506 |
| Uniprot Accession Number |
P17336 |
| Absorption |
|
| Active Site |
ACT_SITE 73; /evidence=ECO:0000255|PROSITE-ProRule:PRU10013; ACT_SITE 146; /evidence=ECO:0000255|PROSITE-ProRule:PRU10013 |
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
CATALYTIC ACTIVITY: Reaction=2 H2O2 = 2 H2O + O2; Xref=Rhea:RHEA:20309, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240; EC=1.11.1.6; Evidence={ECO:0000255|PROSITE-ProRule:PRU10013}; |
| DNA Binding |
|
| EC Number |
1.11.1.6 |
| Enzyme Function |
FUNCTION: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Active site (2); Chain (1); Metal binding (1); Motif (1) |
| Keywords |
Direct protein sequencing;Heme;Hydrogen peroxide;Iron;Metal-binding;Oxidoreductase;Peroxidase;Peroxisome;Reference proteome |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Peroxisome. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
|
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
10353904;
10471706;
10506576;
10526217;
10530784;
10545213;
10638521;
10767577;
10832056;
10924473;
11093245;
11116097;
11167018;
11185567;
11204979;
11250117;
11348656;
11412853;
11525742;
11550893;
11707917;
11719206;
11784000;
11831665;
11998690;
12072463;
12398933;
12417656;
12427535;
12454069;
12470891;
12521602;
12539239;
12715897;
12743125;
12865422;
1325896;
1379030;
1383769;
14576353;
14605208;
14982956;
15013662;
15101064;
15308776;
15621536;
1582561;
15864439;
15954861;
16023296;
16203742;
1651203;
16609144;
1673919;
16906161;
17136098;
17166915;
17194782;
17196240;
17239346;
17248908;
17300838;
17707629;
17928035;
18172893;
18184803;
18284659;
18407920;
18460334;
18627767;
18983909;
19345730;
19348653;
19519625;
19634056;
19770032;
19828196;
19874832;
20015541;
20057353;
20060894;
20184862;
20188393;
20203043;
20220848;
20329357;
20346429;
20371351;
20453260;
20566711;
20600005;
20618965;
20688956;
20869434;
20923705;
21074052;
21108635;
21151574;
21319854;
21372148;
21406223;
21414908;
21512585;
21609775;
21779322;
21987827;
22014527;
22107594;
22197903;
22215442;
22229946;
22288402;
22387531;
22504404;
22529821;
22672579;
22743648;
22758915;
22885802;
22930061;
22940110;
22951642;
22952763;
22991584;
23063786;
23071443;
23159780;
23209438;
23291977;
23355844;
23523639;
23608486;
23628323;
23639798;
23846225;
23879808;
23891756;
23927496;
23944235;
23993264;
24105471;
24149429;
24157427;
24173775;
24183945;
24231732;
24243023;
24380076;
24433322;
24486154;
24555652;
24656823;
24681254;
24756376;
24896182;
24941891;
2503418;
25133314;
25166757;
25226030;
25294943;
25294944;
25345385;
25347746;
25387828;
25398939;
25435894;
25451756;
25478063;
25501370;
25511696;
25557922;
25558754;
25719210;
25776889;
25824290;
25941153;
25988874;
26000719;
26018283;
26026410;
26033662;
26050918;
26060531;
26073628;
26088162;
26095360;
26117601;
26158631;
26159161;
26219626;
26239097;
26259964;
26302912;
26344147;
26366809;
26378456;
26390919;
26431326;
26443856;
26452202;
26453223;
26462024;
26496642;
26526100;
26551273;
26690827;
26758761;
26859353;
26865094;
26875733;
26898463;
26931463;
26944682;
26980113;
26998322;
27172210;
27188745;
27329928;
27335008;
27343351;
27579152;
27582081;
27680705;
27687474;
27701059;
27765625;
27794539;
28069988;
28241105;
28267671;
2830671;
28320100;
28529177;
28634323;
28669604;
28753614;
28827348;
28838288;
28853394;
28881148;
28931163;
28994023;
29018235;
29080449;
29091025;
29093334;
29108774;
29191452;
29191860;
29196499;
29324667;
29357349;
29377237;
29524815;
29563863;
29565247;
29653138;
29670104;
29719584;
29726932;
29727704;
29756514;
29850527;
29897613;
29952680;
29987037;
30001323;
30048948;
30082411;
30110626;
30116484;
30185559;
30188767;
30213494;
30243020;
30263675;
30295966;
30327366;
30353950;
30366679;
30378026;
30510719;
30540251;
30587065;
30635270;
30677014;
30770378;
30802236;
30860988;
30894743;
30899273;
3091448;
31006647;
31040111;
31054025;
31063760;
31073342;
31115476;
31115735;
31242135;
31317820;
31327054;
31353567;
31390561;
31422521;
31425511;
31554796;
31568497;
31584940;
31722958;
31786733;
31794428;
31799578;
31844865;
32019113;
32025502;
32075729;
32118349;
32169171;
32180087;
32284136;
32374658;
32402277;
32429095;
32430858;
32502393;
32523050;
32524642;
32525045;
32544744;
32579905;
32648369;
32664584;
32707222;
32715522;
32747449;
32773682;
32791328;
32796885;
32901612;
32913179;
32930862;
32931926;
32984330;
33069802;
33176146;
33187802;
33199523;
33301922;
33360465;
33360688;
33388406;
33403631;
33449862;
33498013;
33533492;
33544267;
33564101;
33587316;
33669360;
33680062;
33716020;
33748138;
33751817;
33777703;
33852856;
33913484;
33920660;
33940033;
33961967;
33972730;
33990202;
33992327;
34000340;
34204287;
34216545;
34232246;
34348164;
34409649;
34461193;
34481351;
34517133;
34528217;
34531391;
34560124;
34568344;
34625818;
34713801;
34763419;
34849808;
34850846;
35016996;
7479794;
7743390;
7758538;
7797567;
8108730;
8349109;
8543167;
8649466;
8658195;
8658196;
8690025;
8988178;
9053999;
9287428;
9415093;
9467722;
9620757;
9647634;
9790520;
9801075;
9858546;
9866209;
9951621;
|
| Motif |
MOTIF 504..506; /note=Microbody targeting signal; /evidence=ECO:0000255 |
| Gene Encoded By |
|
| Mass |
57,150 |
| Kinetics |
|
| Metal Binding |
METAL 356; /note=Iron (heme axial ligand); /evidence=ECO:0000250 |
| Rhea ID |
RHEA:20309 |
| Cross Reference Brenda |
|