| IED ID | IndEnz0007000044 |
| Enzyme Type ID | catalase000044 |
| Protein Name |
Catalase EC 1.11.1.6 |
| Gene Name | cat |
| Organism | Danio rerio (Zebrafish) (Brachydanio rerio) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Actinopterygii Actinopteri Neopterygii Teleostei Osteoglossocephalai Clupeocephala Otomorpha Ostariophysi Otophysi Cypriniphysae Cypriniformes (carps and others) Cyprinoidei Danionidae Danioninae Danio Danio rerio (Zebrafish) (Brachydanio rerio) |
| Enzyme Sequence | MADDREKSTDQMKLWKEGRGSQRPDVLTTGAGVPIGDKLNAMTAGPRGPLLVQDVVFTDEMAHFDRERIPERVVHAKGAGAFGYFEVTHDITRYSKAKVFEHVGKTTPIVVRFSTVAGEAGSPDTVRDPRGFAVKFYTDEGNWDLTGNNTPTFFIRDTLLSPSFIHSQKRNPQTHLKDPDMVWDFWSLRPESLHQVSFLFSDRGIPDGYRHMNGYGSHTFKLVNAQGQPVYCKFHYKTNQGIKNIPVEEADRLAATDPDYSIRDLYNAIANGNFPSWTFYIQVMTFEQAENWKWNPFDLTKVWSHKEFPLIPVGRFVLNRNPVNYFAEVEQLAFDPSNMPPGIEPSPDKMLQGRLFSYPDTHRHRLGANYLQLPVNCPYRTRVANYQRDGPMCMHDNQGGAPNYYPNSFSAPDVQPRFLESKCKVSPDVARYNSADDDNVTQVRTFFTQVLNEAERERLCQNMAGHLKGAQLFIQKRMVQNLMAVHSDYGNRVQALLDKHNAEGKKNTVHVYSRGGASAVAAASKM |
| Enzyme Length | 526 |
| Uniprot Accession Number | Q9PT92 |
| Absorption | |
| Active Site | ACT_SITE 75; /evidence=ECO:0000255|PROSITE-ProRule:PRU10013; ACT_SITE 148; /evidence=ECO:0000255|PROSITE-ProRule:PRU10013 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=2 H2O2 = 2 H2O + O2; Xref=Rhea:RHEA:20309, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240; EC=1.11.1.6; Evidence={ECO:0000255|PROSITE-ProRule:PRU10013}; |
| DNA Binding | |
| EC Number | 1.11.1.6 |
| Enzyme Function | FUNCTION: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Compositional bias (1); Metal binding (1); Region (1); Sequence conflict (6) |
| Keywords | Heme;Hydrogen peroxide;Iron;Metal-binding;NADP;Oxidoreductase;Peroxidase;Peroxisome;Reference proteome |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Peroxisome {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 17855494; 17898172; 21991373; 28290603; 31178398; |
| Motif | |
| Gene Encoded By | |
| Mass | 59,654 |
| Kinetics | |
| Metal Binding | METAL 358; /note=Iron (heme axial ligand); /evidence=ECO:0000250 |
| Rhea ID | RHEA:20309 |
| Cross Reference Brenda |