| IED ID | IndEnz0007000087 |
| Enzyme Type ID | catalase000087 |
| Protein Name |
Catalase T EC 1.11.1.6 |
| Gene Name | CTT1 YGR088W |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces Saccharomyces cerevisiae (Baker's yeast) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Enzyme Sequence |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|
| Enzyme Length | 562 |
| Uniprot Accession Number | P06115 |
| Absorption | |
| Active Site | ACT_SITE 64; /evidence=ECO:0000255|PROSITE-ProRule:PRU10013; ACT_SITE 137; /evidence=ECO:0000255|PROSITE-ProRule:PRU10013 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=2 H2O2 = 2 H2O + O2; Xref=Rhea:RHEA:20309, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240; EC=1.11.1.6; Evidence={ECO:0000255|PROSITE-ProRule:PRU10013}; |
| DNA Binding | |
| EC Number | 1.11.1.6 |
| Enzyme Function | FUNCTION: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Erroneous initiation (2); Metal binding (1); Sequence conflict (2) |
| Keywords | Cytoplasm;Direct protein sequencing;Heme;Hydrogen peroxide;Iron;Metal-binding;Oxidoreductase;Peroxidase;Reference proteome |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10705040; 10961694; 10978547; 11097021; 11145102; 11283351; 11336700; 11557322; 11679167; 11996093; 12054464; 12586694; 12697341; 12839777; 12859956; 12882320; 14354151; 14558145; 14690591; 15875812; 15893481; 16173060; 16184761; 17009956; 17100288; 17387467; 17576017; 17581878; 17651441; 17925096; 18021067; 18039473; 18082141; 18178164; 18270585; 18452720; 18457571; 1848176; 18489120; 18647484; 18719252; 18768136; 18828915; 18997852; 19196279; 19363031; 19463791; 19536198; 19538506; 19756577; 19801643; 20070446; 20370606; 20585522; 2061315; 20696905; 20846146; 20971184; 21076178; 21081499; 21120656; 21267445; 21437883; 21549177; 21605494; 21713403; 21743437; 21840858; 22084423; 22094416; 22102822; 22209905; 22449970; 22660740; 22662318; 22741594; 22829965; 22848679; 22851651; 22970195; 23167605; 23372015; 23515486; 23793623; 24307284; 24410772; 24418709; 24484434; 24516431; 24563848; 24647101; 24973621; 25065265; 25172136; 25280400; 25416226; 2542766; 25511255; 2557058; 25573485; 25601439; 25640729; 25650342; 26618154; 26851403; 26882930; 27305947; 27388472; 27596631; 27667523; 27883213; 28025392; 28347693; 2844525; 28828388; 30668788; 31235707; 3280971; 3302678; 6293826; 6997287; 7523111; 7565416; 8371123; 8387917; 8398211; 8757790; 8987534; 9272859; 9885153; 9918826; |
| Motif | |
| Gene Encoded By | |
| Mass | 64,583 |
| Kinetics | |
| Metal Binding | METAL 351; /note=Iron (heme axial ligand); /evidence=ECO:0000250 |
| Rhea ID | RHEA:20309 |
| Cross Reference Brenda |