| IED ID | IndEnz0007000652 |
| Enzyme Type ID | catalase000652 |
| Protein Name |
Superoxide dismutase Mn/Fe EC 1.15.1.1 |
| Gene Name | sodA sod |
| Organism | Staphylococcus xylosus |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Firmicutes Bacilli Bacillales Staphylococcaceae Staphylococcus Staphylococcus xylosus |
| Enzyme Sequence | MAFELPNLPYGFDALEPHIDQQTMEIHHGKHHNTYVTKLNAAVEGTDLESKSIEEIVANLDSVPENIQTAVRNNGGGHLNHSLFWELLTPNSEEKGTVVDKIKEQWGSLDAFKEEFADKAAARFGSGWAWLVVNNGNLEIVTTPNQDNPITEGKTPILGLDVWEHAYYLKYQNKRPDYISAFWNVVNWEKVDELYNAAK |
| Enzyme Length | 199 |
| Uniprot Accession Number | Q9K4V3 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:18421; EC=1.15.1.1; Evidence={ECO:0000305|PubMed:11526011};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20697; Evidence={ECO:0000305|PubMed:11526011}; |
| DNA Binding | |
| EC Number | 1.15.1.1 |
| Enzyme Function | FUNCTION: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Catalyzes the dismutation of superoxide anion radicals into O2 and H2O2 by successive reduction and oxidation of the transition metal ion at the active site. Also contributes to the inhibition of lipid oxidation. Manganese-preferring enzyme, less active with iron than with manganese. {ECO:0000269|PubMed:11470359, ECO:0000269|PubMed:11526011}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Metal binding (8); Natural variant (14); Sequence conflict (1) |
| Keywords | Iron;Manganese;Metal-binding;Oxidoreductase;Stress response |
| Interact With | |
| Induction | INDUCTION: Transcription increases slightly by internally generated superoxide stress. {ECO:0000269|PubMed:11526011}. |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 22,535 |
| Kinetics | |
| Metal Binding | METAL 27; /note=Fe(3+); via tele nitrogen; /evidence=ECO:0000250|UniProtKB:P80293; METAL 27; /note=Manganese; via tele nitrogen; /evidence=ECO:0000250|UniProtKB:P80293; METAL 81; /note=Fe(3+); via tele nitrogen; /evidence=ECO:0000250|UniProtKB:P80293; METAL 81; /note=Manganese; via tele nitrogen; /evidence=ECO:0000250|UniProtKB:P80293; METAL 161; /note=Fe(3+); /evidence=ECO:0000250|UniProtKB:P80293; METAL 161; /note=Manganese; /evidence=ECO:0000250|UniProtKB:P80293; METAL 165; /note=Fe(3+); via tele nitrogen; /evidence=ECO:0000250|UniProtKB:P80293; METAL 165; /note=Manganese; via tele nitrogen; /evidence=ECO:0000250|UniProtKB:P80293 |
| Rhea ID | RHEA:20696; RHEA:20697 |
| Cross Reference Brenda |