| IED ID | IndEnz0007000666 |
| Enzyme Type ID | catalase000666 |
| Protein Name |
Cell surface superoxide dismutase Cu-Zn 6 EC 1.15.1.1 Predicted GPI-anchored protein 9 |
| Gene Name | SOD6 PGA9 SOD33 CAALFM_C200240CA CaO19.2108 CaO19.9656 |
| Organism | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Debaryomycetaceae Candida/Lodderomyces clade Candida Candida albicans (Yeast) Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
| Enzyme Sequence | MIFIPIIILIYLVSIAASDKSPKIKKNPRNVVAVADFPFGGDTQVKGNVVFSAKEGKHVNVHIDMTGLPKDEGPFFYHIHERSVPGNGNCEAVGLHFNPYNASPVCDEQKNDAYCQVGDLSGKHGCINTTCFELKYSDPYLSLNRKSKSYIIGKSVVFHYPNLTKIACADIEEANELRLQSLIDEYTQTDDAIQLKELNTPLETDYKFDEVEALSSEIYHSDTDSDPPQQELISTEKLYNKTDNVYSPEETRPSDQNKKSHRHSLLPLAKWKKNSPKNYSNISIHGISSDCLNDGMMVTGSVFGSLVLGIAAGIFV |
| Enzyme Length | 316 |
| Uniprot Accession Number | Q5ACV9 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:18421; EC=1.15.1.1; |
| DNA Binding | |
| EC Number | 1.15.1.1 |
| Enzyme Function | FUNCTION: Superoxide dismutases serve to convert damaging superoxide radicals, a key form of ROS, to less damaging hydrogen peroxide that can be converted into water by catalase action. May be involved protection against extracellular stress. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Glycosylation (5); Lipidation (1); Metal binding (6); Propeptide (1); Region (1); Signal peptide (1) |
| Keywords | Antioxidant;Cell wall;Copper;GPI-anchor;Glycoprotein;Lipoprotein;Membrane;Metal-binding;Oxidoreductase;Reference proteome;Secreted;Signal;Virulence;Zinc |
| Interact With | |
| Induction | INDUCTION: Unlike SOD4 and SOD5, SOD6 is not regulated during yeast to hyphae transition or by temperature. Up-regulated during biofilm formation and expression is controlled by HAP43. {ECO:0000269|PubMed:16151249, ECO:0000269|PubMed:19019164, ECO:0000269|PubMed:21592964}. |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted, cell wall. Membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Note=Covalently-linked GPI-modified cell wall protein (GPI-CWP). {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | PTM: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity). {ECO:0000250}. |
| Signal Peptide | SIGNAL 1..18; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 35,110 |
| Kinetics | |
| Metal Binding | METAL 78; /note=Copper; catalytic; /evidence=ECO:0000250; METAL 80; /note=Copper; catalytic; /evidence=ECO:0000250; METAL 96; /note=Copper; catalytic; /evidence=ECO:0000250; METAL 96; /note=Zinc; structural; /evidence=ECO:0000250; METAL 119; /note=Zinc; structural; /evidence=ECO:0000250; METAL 159; /note=Copper; catalytic; /evidence=ECO:0000250 |
| Rhea ID | RHEA:20696 |
| Cross Reference Brenda |