| IED ID | IndEnz0007000668 |
| Enzyme Type ID | catalase000668 |
| Protein Name |
Transcriptional regulator SdrP Cyclic AMP receptor protein/Fumarate and nitrate reduction regulator superfamily protein SdrP CRP/FNR superfamily protein SdrP Oxidative stress-responsive transcriptional activator SdrP Stationary phase-dependent regulatory protein SdrP |
| Gene Name | TTHA1359 |
| Organism | Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Deinococcus-Thermus Deinococci Thermales Thermaceae Thermus Thermus thermophilus Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) |
| Enzyme Sequence | MTQVRETVSFKAGDVILYPGVPGPRDRAYRVLEGLVRLEAVDEEGNALTLRLVRPGGFFGEEALFGQERIYFAEAATDVRLEPLPENPDPELLKDLAQHLSQGLAEAYRRIERLATQRLKNRMAAALLELSETPLAHEEEGKVVLKATHDELAAAVGSVRETVTKVIGELAREGYIRSGYGKIQLLDLKGLKELAESRGQGR |
| Enzyme Length | 202 |
| Uniprot Accession Number | Q5SIL0 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | DNA_BIND 149..168; /note=H-T-H motif; /evidence=ECO:0000255|PROSITE-ProRule:PRU00387 |
| EC Number | |
| Enzyme Function | FUNCTION: Activates transcription. The consensus DNA-binding site of this transcriptional regulator is 5'-WWGTGAN(5-7)ACACWW-3' in which W is A or T and N is G, A, T or C. Regulated genes include those encoding proteins involved in nutrient and energy supply, redox control and polyadenylation of mRNA (PubMed:18699868). Also regulates genes involved in oxidative stress response such as genes encoding manganese superoxide dismutase and catalase, and genes encoding a protein involved in nucleotide excision repair of damaged DNA and putative proteins involved in redox control, protein degradation and transcriptional regulation (PubMed:21054499). {ECO:0000269|PubMed:18699868, ECO:0000269|PubMed:21054499}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (12); Chain (1); DNA binding (1); Domain (1); Helix (6); Initiator methionine (1) |
| Keywords | 3D-structure;DNA-binding;Direct protein sequencing;Reference proteome;Transcription;Transcription regulation |
| Interact With | |
| Induction | INDUCTION: Increased expression during the stationary phase when grown at 70 degrees Celsius (PubMed:18699868). Increased expression during the logarithmic growth phase in oxidative stress and upon treatment with diamide. Increased expression by heavy metal ion, antibiotic, high salt and organic solvent stresses (PubMed:21054499). {ECO:0000269|PubMed:18699868, ECO:0000269|PubMed:21054499}. |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 2ZCW; |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 22,317 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |