| IED ID | IndEnz0008000226 |
| Enzyme Type ID | cellulase000226 |
| Protein Name |
Protein CELLULOSE SYNTHASE INTERACTIVE 1 Protein POM-POM 2 |
| Gene Name | CSI1 POM2 At2g22125 T16B14.2 |
| Organism | Arabidopsis thaliana (Mouse-ear cress) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress) |
| Enzyme Sequence | MTSALGWRFPSTNGNGLAPSDTERNGDMKMHDSEPPTPHSTTKMSLRDRTTSMEDPDGTLASVAQCIEQLRQGSSSAQEREYCLKQLLDLIEMRENAFSAVGSHSQAVPVLVSLLRSGSVGVKIQAATVLGSLCKENELRVKVLLGGCIPPLLGLLKSSSVEGQIAAAKTIYAVSEGGVKDHVGSKIFSTEGVVPVLWDQLRSGNKKGEVDGLLTGALKNLSSTTEGFWSETIRAGGVDVLVKLLTSGQSSTLSNVCFLLACMMMEDASVCSSVLTADITKQLLKLLGSGNEAPVRAEAAAALKSLSAQSKEAKREIANSNGIPVLINATIAPSKEFMQGEYAQALQENAMCALANISGGLSYVISSLGQSLESCSSPAQTADTLGALASALMIYDGKAETTRASDPLVVEQTLLKQFKPRLPFLVQERTIEALASLYGNSILSVKLSNSDAKRLLVGLITMAVNEVQDELVKALLMLCNHEGSLWQALQGREGIQLLISLLGLSSEQQQECAVALLCLLSNENDESKWAITAAGGIPPLVQILETGSAKAREDSATILRNLCNHSEDIRACVESADAVPALLWLLKNGSPNGKEIAAKTLNHLIHKSDTATISQLTALLTSDLPESKIYVLDALKSMLSVVPFNDMLREGSASNDAIETMIKLMSSGKEETQANSASALAAIFQSRKDLRESALALKTLLSAIKLLNVDSERILVESCRCLAAILLSIKENRDVAISAREALPTIVSLANSSVLEVAEQGMCALANLILDSEVSEKVIVEDIILSATRILREGTVSGKTLAAAAIARLLSRRRIDSALTDSVNRAGTVLTLVSLLESADGRSDAISEALDALAIFSRSGANGNVKPAWAVLAESPNSMAPIVSSIVSVANPSLQDKAIEVLSRLCRDQPIVLGNMVNNARDCVSSIAKRVINTRDPKIKIGGAAIIICAAKVDDQKMIENLNETQLCAKFVQALVGILDSVQDQEKDEKDKICICIHPKEKEEDEEEEATENREGSTGATVISGDNLAIWLLSVLSCHDEKSRAVILESEGIELITDRIGNRFLQADNGEDANIWVCALLLAILFQDREITRAHATMKAVPVLSNLVKSEEYADRYFAAQALASLVCNGSRGTLLSVANSGAAAGFISLLGCSDDDIKELLQLSQEFTLVRYPDQVALERLFRVEDIRVGATSRKAIPLLVELLKPIPDRPGAPLLSLNLLTQLAGDCPQNMIVMVESGALEGLSKYLSLGPQDEQEEAATGLLGILFSSAEIRRHESAFGAVSQLVAVLRLGGRGARYSAAKALDSLFTADHIRNAESSRQAVQPLVEILNTGSEREQHAAIAALVRLLSDNPSRALAVADVEMNAVDVLCRILSSNYTMELKGDAAELCYVLFANTRIRSTVAAARCVEPLVSLLVTEFSPAQHSVVRALDKLVDDEQLAELVAAHGAVVPLVGLLYGKNYVLHEAISRALVKLGKDRPACKLEMVKAGVIDCVLDILHEAPDFLCAAFSELLRILTNNATIAKGQSAAKVVEPLFHLLTRLEFGADGQHSALQVLVNILEHPQCRADYTLTPHQVIEPLIPLLESPSPAVQQLAAELLSHLLYEEHLQKDPLTQLAIGPLIHVLGSGIHLLQQRAVKALVSIALTWPNEIAKEGGVSELSKVILQADPSLSNVLWESAASILVIILQFSSEFYLEVPVAVLVRLLRSASENTVVGALNALLVLESDDGTSAESMAESGAIEALLDLLRSHQCEDTAARLLEVLLNNVKIRDSKATKTAILPLSQYLLDPQTQAQQARLLATLALGDLFQNEALARSTDAASACRALVNVLEEQPTEEMKVVAICALQNLVMYSRSNKRAVAEAGGVQVVLDLISSSDPETSVQAAMFVKLLFSNHTVQEYASSETVRAITAAIEKDLWATGTVNDEYLKALNSLFNNFPRLRATEPATLSIPHLVTSLKTGSEATQEAALDALFLLRQAWSACPAEVSRAQSVAAADAIPLLQYLIQSGPPRFQEKAEFLLQCLPGTLVVTIKRGNNMKQSVGNPSVFCKITLGNNPPRQTKVISTGPNPEWDESFSWSFESPPKGQKLHISCKNKSKMGKSSFGKVTIQIDRVVMLGAVAGEYSLLPESKSGPRNLEIEFQWSNK |
| Enzyme Length | 2150 |
| Uniprot Accession Number | F4IIM1 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Regulator of the microtubular cytoskeleton (PubMed:22427339). Microtubule-associated protein essential for the functional association of cellulase synthase (CESA) complexes (CSCs) and cortical microtubules (PubMed:22294619, PubMed:22190487, PubMed:22751327, PubMed:23623553, PubMed:24368796). Promotes dynamics of CSCs in the plasma membrane (PubMed:21150290, PubMed:20616083, PubMed:22294619, PubMed:22190487, PubMed:22751327, PubMed:23623553, PubMed:24368796). Regulates primary cell wall biosynthesis and cellulose microfibrils organization (PubMed:21150290, PubMed:20616083, PubMed:23623553). Required for the regulation of root cell elongation/expansion (PubMed:7743935, PubMed:21150290, PubMed:20616083, PubMed:22294619, PubMed:22427339). Necessary for the formation of ovules, pollen cell wall morphogenesis and pollen tube development (PubMed:22294619). Involved in anther dehiscence, via dehydration-induced microtubule depolymerization and reorganization. May play a role in early gynoecial development (PubMed:22427339). {ECO:0000269|PubMed:20616083, ECO:0000269|PubMed:21150290, ECO:0000269|PubMed:22190487, ECO:0000269|PubMed:22294619, ECO:0000269|PubMed:22427339, ECO:0000269|PubMed:22751327, ECO:0000269|PubMed:23623553, ECO:0000269|PubMed:24368796, ECO:0000269|PubMed:7743935}.; FUNCTION: Target of the cellulase synthase (CESA) complexes (CSCs) trafficking inhibitor CESTRIN, which reduces cellulose content and alters anisotropic growth of hypocotyls; CESTRIN treatment inhibits the dynamics of CSCs. {ECO:0000269|PubMed:25535279}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (1); Domain (1); Erroneous gene model prediction (2); Erroneous initiation (1); Region (1); Repeat (41); Sequence conflict (2) |
| Keywords | Cell membrane;Cell shape;Cell wall biogenesis/degradation;Cytoplasm;Cytoskeleton;Developmental protein;Golgi apparatus;Growth regulation;Membrane;Reference proteome;Repeat |
| Interact With | Q94JQ6 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20616083, ECO:0000269|PubMed:22190487, ECO:0000269|PubMed:22294619, ECO:0000269|PubMed:22751327, ECO:0000269|PubMed:24368796}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus {ECO:0000269|PubMed:22294619}. Endomembrane system {ECO:0000269|PubMed:22294619}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22190487, ECO:0000269|PubMed:22294619, ECO:0000269|PubMed:22427339}. Note=Undergoes dynamic changes in response to dehydration (PubMed:22427339). Colocalizes with cellulase synthase (CESA) complexes (CSCs) in a dynamic way, both at the plasma membrane and in post-Golgi compartments (PubMed:24368796, PubMed:20616083, PubMed:22294619, PubMed:22190487). Present in distinct punctae at the cell cortex, called microtubule-associated cellulose synthase compartments, that move with constant velocities of 200 to 300 nm/min (PubMed:22294619). Present with cortical microtubule depolymerizing ends (PubMed:22294619, PubMed:22190487). {ECO:0000269|PubMed:20616083, ECO:0000269|PubMed:22190487, ECO:0000269|PubMed:22294619, ECO:0000269|PubMed:22427339, ECO:0000269|PubMed:24368796}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 17644812; 18650403; 21166475; 25077797; 26432860; 26443667; 26503768; 26829351; 27247031; 27477947; 28947492; 29581258; 32016356; |
| Motif | |
| Gene Encoded By | |
| Mass | 230,706 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |