| IED ID |
IndEnz0008000380 |
| Enzyme Type ID |
cellulase000380 |
| Protein Name |
C2H2 type master regulator of conidiophore development brlA
|
| Gene Name |
brlA PDE_00087 |
| Organism |
Penicillium oxalicum (strain 114-2 / CGMCC 5302) (Penicillium decumbens) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Fungi
Dikarya
Ascomycota
saccharomyceta
Pezizomycotina
leotiomyceta
Eurotiomycetes
Eurotiomycetidae
Eurotiales (green and blue molds)
Aspergillaceae
Penicillium
Penicillium oxalicum
Penicillium oxalicum (strain 114-2 / CGMCC 5302) (Penicillium decumbens)
|
| Enzyme Sequence |
MRTQGQQISDRLTVEVDCHSLGPADCPSMTSSFSPLESPTPTPTSLYSHGSLTSPSWHEAGHYHSLPMERRPSGTPLRNAFRVTDFPSADPMGMQVGTMERPDQLPVSSEYLSGYDDINDQLWIPHDSIPKTFEHPTFPYQAPMPQYHHTMGRNHYYRPQAHTAYLPESASNPCLSRPMFSRHDGLSHSASMSNMLPWMTAPESLAPQTITPQQAFPGAGPVTPPSSNYSDFPASLQTFKPHTPSTPVRSLSLGTPRSDTPQSRMSGHYDYSEEYPVSPVYRDGHLIRTHRQPSRKPSKKQLVRSNLSLEKLPPIIKQVQFKCKEPGCKGRFKRQEHLKRHMKSHSKEKPHVCWVPGCHRAFSRSDNLNAHYTKTHSKRGGRNRYVATLDETSPDYDPEFRGQLTPDGRPIYGSKLEDLADCDLSVDGWED |
| Enzyme Length |
431 |
| Uniprot Accession Number |
S7Z906 |
| Absorption |
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| Active Site |
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| Activity Regulation |
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| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
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| DNA Binding |
|
| EC Number |
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| Enzyme Function |
FUNCTION: BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation (PubMed:24113825). They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (By similarity). Binds promoters of target genes at brlA response elements (BREs) containing the conserved sequence 5'-(C/A)(A/G)AGGG(G/A)-3' (By similarity). Regulates the expression levels of seven secondary metabolism gene clusters including a down-regulated cluster putatively involved in the biosynthesis of the mycotoxins roquefortine C and meleagrin (PubMed:24113825). Negatively regulates the expression of cellulase genes (PubMed:24113825). {ECO:0000250|UniProtKB:P22022, ECO:0000269|PubMed:24113825}. |
| Temperature Dependency |
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| PH Dependency |
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| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Compositional bias (1); Region (4); Zinc finger (2) |
| Keywords |
Activator;Conidiation;DNA-binding;Metal-binding;Nucleus;Reference proteome;Repeat;Sporulation;Transcription;Transcription regulation;Zinc;Zinc-finger |
| Interact With |
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| Induction |
INDUCTION: Expression is controlled by the casein kinase CK2 (PubMed:24613994). {ECO:0000269|PubMed:24613994}. |
| Subcellular Location |
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P10069}. |
| Modified Residue |
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| Post Translational Modification |
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| Signal Peptide |
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| Structure 3D |
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| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
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| Gene Encoded By |
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| Mass |
48,585 |
| Kinetics |
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| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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