| IED ID | IndEnz0008000529 |
| Enzyme Type ID | cellulase000529 |
| Protein Name |
Developmental and secondary metabolism regulator VEL1 Velvet complex subunit 1 |
| Gene Name | VEL1 VeA TRIREDRAFT_122284 |
| Organism | Hypocrea jecorina (strain QM6a) (Trichoderma reesei) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta sordariomyceta Sordariomycetes Hypocreomycetidae Hypocreales Hypocreaceae Trichoderma Hypocrea jecorina (Trichoderma reesei) Hypocrea jecorina (strain QM6a) (Trichoderma reesei) |
| Enzyme Sequence | MATPSSVASSSSRDQVQRIHRVTRENRHLWYQLTVLQQPERARACGSGMKANSDRRPVDPPPVVELRIIEGPSVEEGKDITFDYNANFFLYASLEQARTIAHGRVQNGATNNPPILTGVPASGMAYLDRPTEAGYFIFPDLSVRHEGYFRLSFSLYETTKEPKDFDLEPADSDLPPGVDWRMEIKTQPFNVFSAKKFPGLMESTSLSKTVADQGCRVRIRRDVRMRKRDGKGSGFDRRGEEEYSRRRTVTPAPAEDPNLRARSVSNASEHRGPYMPQEPPRRPSAAESYHAPPPLPPPPPSSYDAPPPAARPGHLGFGGDHNMPPQYGAPAARPYGHPQSAPIPPATPTGPYPTSSAAPSPYAKQDHHHQQQYSYNSRPPAPSASPAPPMKHAMYDNRPSEPYVPHSSPSVYASTERRPSYANYSAPAPYSTPASQPTYSTPASQPTYSTPASQPTYSAPPPAPYSAPAPPPPRPSMSQSSLAPLKIASLVSPLPPIEAQTEPLPPPPMLSTGGKRKHDHVFSQNHKPLYNGQRQLDAHYGHGYRGLTPEPDQGLYSRADGQIGVVTFNQYQV |
| Enzyme Length | 573 |
| Uniprot Accession Number | G0RL42 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination (PubMed:25386652). The velvet complex hat acts as a global regulator for secondary metabolite gene expression (By similarity). Regulates expression of the carbohydrate-active enzyme gene clusters (PubMed:25386652). {ECO:0000250|UniProtKB:C8VTV4, ECO:0000269|PubMed:25386652}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (6); Domain (1); Motif (1); Region (2) |
| Keywords | Cytoplasm;Nucleus;Reference proteome;Sporulation;Transcription;Transcription regulation |
| Interact With | |
| Induction | INDUCTION: Expression is regulated by light and darkness, but this regulation is further modulated by the carbon source in relation to the growth rate (PubMed:25386652). Expression is under the control of LAE1 (PubMed:23390613). {ECO:0000269|PubMed:23390613, ECO:0000269|PubMed:25386652}. |
| Subcellular Location | SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:C8VTV4}. Cytoplasm {ECO:0000250|UniProtKB:C8VTV4}. Note=Enriched in the nucleus in the dark (By similarity). {ECO:0000250|UniProtKB:C8VTV4}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 40..45; /note=Nuclear localization signal; /evidence=ECO:0000250|UniProtKB:C8VTV4 |
| Gene Encoded By | |
| Mass | 62,878 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |