| IED ID |
IndEnz0008000571 |
| Enzyme Type ID |
cellulase000571 |
| Protein Name |
Velvet complex subunit 2
|
| Gene Name |
VEL2 TRIREDRAFT_40551 |
| Organism |
Hypocrea jecorina (strain QM6a) (Trichoderma reesei) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Fungi
Dikarya
Ascomycota
saccharomyceta
Pezizomycotina
leotiomyceta
sordariomyceta
Sordariomycetes
Hypocreomycetidae
Hypocreales
Hypocreaceae
Trichoderma
Hypocrea jecorina (Trichoderma reesei)
Hypocrea jecorina (strain QM6a) (Trichoderma reesei)
|
| Enzyme Sequence |
MPSLIPPIVSASSASNSAALDHLYHHQPPPRLPLGAVPQSPIQSQAPPPPHLHPPSHHFQLHPGHGHHQQPHHERDHRLPPPVASYSAHSHHLQHDPLPQRLESSQPGHPGAAEHRDHPQHALDEPSRSHDPYPSMATGALVHSESQQPASASLLLPISNVEEATGRRYHLDVVQQPRRARMCGFGDKDRRPITPPPCVRLIIIDVATGKEIDCNDIDHSMFVLNVDLWNEDGTREVNLVRSSTSSSPSVSSTVTYPYGSISVGESSHTYGQSAHPPSREAPYSVSQTASYAPEYQTQPTYSQGSSAYPSNGTYGPPQQYFPQHQAYRTETGPPGAMQTTVGGFRGYAQDQNALTKMAVVGGQPQGMFTRNLIGSLAASAFRLADTSEHLGIWFVLQDLSVRTEGPFRLRFSFVNVGPLAGQNGAKVNTGRAPILASCFSEVFNVYSAKKFPGVCESTPLSKTFAAQGIKIPIRKDANLKGGDGEDDYGD |
| Enzyme Length |
490 |
| Uniprot Accession Number |
G0RS98 |
| Absorption |
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| Active Site |
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| Activity Regulation |
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| Binding Site |
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| Calcium Binding |
|
| catalytic Activity |
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| DNA Binding |
|
| EC Number |
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| Enzyme Function |
FUNCTION: Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination (By similarity). The velvet complex acts as a global regulator for secondary metabolite gene expression (By similarity). Component of the VEL2-VOS1 heterodimeric complex that plays a dual role in activating genes associated with spore maturation and repressing certain development-associated genes (By similarity). The VEL2-VOS1 complex binds DNA through the DNA-binding domain of VOS1 that recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3' consisting of two motifs in the promoters of key developmental regulatory genes (By similarity). Regulates expression of cellulase-encoding genes such as the cellobiohydrolase-encoding genes cbh1 and cbh2, the endo-beta-1,4-glucanase-encoding genes egl1 and egl2, and the beta-glucosidase-encoding gene bgl1 (PubMed:26481618). {ECO:0000250|UniProtKB:C8VTS4, ECO:0000269|PubMed:26481618}. |
| Temperature Dependency |
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| PH Dependency |
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| Pathway |
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| nucleotide Binding |
|
| Features |
Chain (1); Compositional bias (2); Domain (1); Erroneous gene model prediction (1); Region (2) |
| Keywords |
Cytoplasm;Nucleus;Reference proteome;Sporulation;Transcription;Transcription regulation |
| Interact With |
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| Induction |
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| Subcellular Location |
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:C8VTS4}. Cytoplasm {ECO:0000250|UniProtKB:C8VTS4}. Note=Nuclear localization is mediated by VEL1 (By similarity). {ECO:0000250|UniProtKB:C8VTS4}. |
| Modified Residue |
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| Post Translational Modification |
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| Signal Peptide |
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| Structure 3D |
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| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
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| Gene Encoded By |
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| Mass |
53,139 |
| Kinetics |
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| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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