IED Industry Enzyme Database

Detail Information for IndEnz0009000011
IED ID IndEnz0009000011
Enzyme Type ID chitinase000011
Protein Name Chitinase-3-like protein 1
39 kDa synovial protein
Cartilage glycoprotein 39
CGP-39
GP-39
hCGP-39
YKL-40
Gene Name CHI3L1
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MGVKASQTGFVVLVLLQCCSAYKLVCYYTSWSQYREGDGSCFPDALDRFLCTHIIYSFANISNDHIDTWEWNDVTLYGMLNTLKNRNPNLKTLLSVGGWNFGSQRFSKIASNTQSRRTFIKSVPPFLRTHGFDGLDLAWLYPGRRDKQHFTTLIKEMKAEFIKEAQPGKKQLLLSAALSAGKVTIDSSYDIAKISQHLDFISIMTYDFHGAWRGTTGHHSPLFRGQEDASPDRFSNTDYAVGYMLRLGAPASKLVMGIPTFGRSFTLASSETGVGAPISGPGIPGRFTKEAGTLAYYEICDFLRGATVHRILGQQVPYATKGNQWVGYDDQESVKSKVQYLKDRQLAGAMVWALDLDDFQGSFCGQDLRFPLTNAIKDALAAT
Enzyme Length 383
Uniprot Accession Number P36222
Absorption
Active Site
Activity Regulation
Binding Site BINDING 141; /note=Chitooligosaccharide; /evidence=ECO:0000255|PROSITE-ProRule:PRU01258; BINDING 263; /note=Chitooligosaccharide; BINDING 352; /note=Chitooligosaccharide; /evidence=ECO:0000255|PROSITE-ProRule:PRU01258
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung. {ECO:0000269|PubMed:16472595, ECO:0000269|PubMed:19414556, ECO:0000269|PubMed:20558631, ECO:0000269|PubMed:9492324}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Beta strand (17); Binding site (3); Chain (1); Disulfide bond (2); Domain (1); Glycosylation (1); Helix (19); Natural variant (2); Region (4); Signal peptide (1); Turn (6)
Keywords 3D-structure;Antimicrobial;Apoptosis;Asthma;Cytoplasm;Direct protein sequencing;Disulfide bond;Endoplasmic reticulum;Glycoprotein;Inflammatory response;Lectin;Reference proteome;Schizophrenia;Secreted;Signal
Interact With Q14627; P17931
Induction INDUCTION: Up-regulated in colon under several inflammatory conditions. Down-regulated by hyperoxia in bronchial epithelial cells. {ECO:0000269|PubMed:16472595, ECO:0000269|PubMed:20558631}.
Subcellular Location SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:9492324}. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
Modified Residue
Post Translational Modification PTM: Glycosylated. {ECO:0000269|PubMed:12775711}.
Signal Peptide SIGNAL 1..21; /evidence="ECO:0000269|PubMed:2375755, ECO:0000269|PubMed:9492324"
Structure 3D X-ray crystallography (7)
Cross Reference PDB 1HJV; 1HJW; 1HJX; 1NWR; 1NWS; 1NWT; 1NWU;
Mapped Pubmed ID 11986266; 12069012; 12071845; 12435396; 12759455; 12799184; 12933821; 12957359; 14555515; 15569925; 15788675; 15829322; 15867231; 16234240; 16818690; 16955240; 16960935; 17020973; 17236752; 17543889; 17545529; 17565739; 17599744; 17712177; 17957792; 18054022; 18092325; 18157633; 18182077; 18190830; 18217402; 18280741; 18281018; 18480670; 18490894; 18570155; 18615353; 18650368; 18708058; 18723551; 18767121; 18802121; 18957531; 19003601; 19070929; 19089918; 19106306; 19197227; 19200605; 19255724; 19264973; 19308408; 19421404; 19536175; 19550125; 19568425; 19644363; 19666003; 19694834; 19701838; 19765801; 19767768; 19961288; 20012147; 20047081; 20056225; 20099501; 20174854; 20224722; 20226308; 20300754; 20347092; 20356987; 20424473; 20499402; 20506295; 20538957; 20540736; 20640910; 20650887; 20656949; 20674561; 20800603; 20840668; 20926018; 20943784; 20961744; 20972697; 21029458; 21143859; 21159401; 21159721; 21257319; 21272568; 21385870; 21391238; 21478032; 21496058; 21530869; 21642896; 21714862; 21715039; 21782391; 21820815; 21831900; 21858537; 21934681; 21949714; 21953450; 21968467; 21978279; 22036069; 22056877; 22074331; 22095223; 22103814; 22140133; 22146624; 22183936; 22209156; 22211103; 22281830; 22351690; 22366530; 22433444; 22480951; 22525348; 22534532; 22554524; 22572101; 22583189; 22628227; 22642467; 22647735; 22655594; 22809439; 22937056; 22955689; 22986489; 22989351; 23071724; 23149946; 23190377; 23197259; 23226395; 23227243; 23272150; 23279705; 23291472; 23294528; 23364142; 23397672; 23490418; 23501042; 23525579; 23551676; 23562456; 23573226; 23591413; 23613996; 23628340; 23650620; 23665676; 23671604; 23706599; 23792508; 23840582; 23918300; 24256818; 24309227; 24324091; 24405178; 24440516; 24442412; 24498368; 24512683; 24572981; 24582001; 24650028; 24685381; 24689875; 24691276; 24729664; 24730590; 24801872; 24808626; 24814404; 24842123; 24861484; 24878721; 24920662; 24954373; 24958781; 24981110; 25001061; 25024322; 25047113; 25051073; 25056157; 25068525; 25128003; 25139333; 25142236; 25172968; 25172979; 25203433; 25225167; 25262987; 25270518; 25304157; 25343670; 25400457; 25412935; 25421412; 25486056; 25497736; 25519006; 25545245; 25573204; 25592985; 25629266; 25629580; 25657159; 25688078; 25698171; 25740558; 25760838; 25875173; 25909875; 25941933; 25955771; 25976273; 26002577; 26095694; 26121745; 26125767; 26142786; 26197239; 26270969; 26275425; 26295543; 26301577; 26303257; 26316585; 26372680; 26382922; 26415140; 26427144; 26431492; 26452028; 26466985; 26523896; 26603717; 26620310; 26696093; 26698298; 26698539; 26733160; 26779637; 26781979; 26782508; 26828595; 26935740; 26988273; 26988593; 27069189; 27090900; 27121858; 27152377; 27170664; 27179219; 27187575; 27193312; 27374825; 27385098; 27427920; 27575987; 27616735; 27629921; 27650381; 27653898; 27668705; 27732738; 27739482; 27760764; 27801851; 27832767; 27881022; 27977409; 27977724; 28009325; 28036271; 28053085; 28099248; 28143526; 28211584; 28260989; 28281838; 28285848; 28303416; 28324830; 28368410; 28384116; 28448439; 28569052; 28599675; 28624692; 28639986; 28660216; 28681574; 28697565; 28711881; 28739286; 28797750; 28932021; 28941940; 28989002; 29025889; 29028081; 29112186; 29126445; 29209110; 29233108; 29274508; 29324810; 29336711; 29357700; 29400369; 29430175; 29452694; 29580282; 29642772; 29643433; 29729901; 29737637; 29783062; 29797629; 29804188; 29806605; 29848684; 29921378; 29949801; 29970479; 29981861; 30019588; 30061245; 30111325; 30121622; 30165890; 30223258; 30224549; 30258444; 30301907; 30341592; 30402955; 30431458; 30471784; 30523734; 30560917; 30584894; 30660494; 30688121; 30940096; 30948312; 30952886; 30978656; 30988078; 31021016; 31115541; 31231798; 31247206; 31256192; 31295039; 31310926; 31397016; 31427175; 31455178; 31482369; 31487401; 31490625; 31536166; 31563729; 31685562; 31837465; 31856080; 31916309; 31937582; 32066474; 32127023; 32162865; 32170669; 32250575; 32276601; 32312371; 32367614; 32500186; 32568193; 32571644; 32613636; 32654211; 32721792; 32786104; 32791244; 32816366; 32876843; 32920471; 32929074; 32933994; 32962417; 33031973; 33061832; 33095949; 33186077; 33200966; 33212158; 33274678; 33277205; 33280245; 33327838; 33328329; 33347699; 33352356; 33486888; 33508452; 33622872; 33652290; 33664231; 33764958; 33870790; 33888584; 33920100; 33991015; 34020736; 34088622; 34110111; 34164774; 34168643; 34170085; 34228644; 34259106; 34274729; 34417838; 34432260; 34436040; 34498339; 34526107; 34579512; 34612767; 34627195; 34637032; 34747367; 34790051; 34935995; 34942410; 35033868; 35042079; 35144413; 35222369;
Motif
Gene Encoded By
Mass 42,625
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda