| IED ID | IndEnz0009000012 |
| Enzyme Type ID | chitinase000012 |
| Protein Name |
Chitinase-3-like protein 2 Chondrocyte protein 39 YKL-39 |
| Gene Name | CHI3L2 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MGATTMDQKSLWAGVVVLLLLQGGSAYKLVCYFTNWSQDRQEPGKFTPENIDPFLCSHLIYSFASIENNKVIIKDKSEVMLYQTINSLKTKNPKLKILLSIGGYLFGSKGFHPMVDSSTSRLEFINSIILFLRNHNFDGLDVSWIYPDQKENTHFTVLIHELAEAFQKDFTKSTKERLLLTAGVSAGRQMIDNSYQVEKLAKDLDFINLLSFDFHGSWEKPLITGHNSPLSKGWQDRGPSSYYNVEYAVGYWIHKGMPSEKVVMGIPTYGHSFTLASAETTVGAPASGPGAAGPITESSGFLAYYEICQFLKGAKITRLQDQQVPYAVKGNQWVGYDDVKSMETKVQFLKNLNLGGAMIWSIDMDDFTGKSCNQGPYPLVQAVKRSLGSL |
| Enzyme Length | 390 |
| Uniprot Accession Number | Q15782 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | BINDING 104; /note="Chitooligosaccharide"; /evidence="ECO:0000269|PubMed:22742450"; BINDING 146; /note="Chitooligosaccharide"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01258, ECO:0000269|PubMed:22742450"; BINDING 213; /note="Chitooligosaccharide"; /evidence="ECO:0000269|PubMed:22742450"; BINDING 360; /note="Chitooligosaccharide"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01258, ECO:0000269|PubMed:22742450" |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity. {ECO:0000269|PubMed:22742450}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (2); Beta strand (14); Binding site (4); Chain (1); Disulfide bond (1); Domain (1); Erroneous initiation (2); Glycosylation (1); Helix (16); Mutagenesis (2); Natural variant (3); Region (3); Signal peptide (1); Turn (6) |
| Keywords | 3D-structure;Alternative splicing;Chitin-binding;Direct protein sequencing;Disulfide bond;Glycoprotein;Hydrolase;Lectin;Reference proteome;Secreted;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..26 |
| Structure 3D | X-ray crystallography (5) |
| Cross Reference PDB | 4AY1; 4P8U; 4P8V; 4P8W; 4P8X; |
| Mapped Pubmed ID | 12435396; 20379614; 20711500; 22190034; 22211103; 23291184; 25477513; 25609649; 25698171; 26733160; 27653898; 28989002; 29728799; 31810965; 32038607; 33828170; 34164774; 34395626; |
| Motif | |
| Gene Encoded By | |
| Mass | 43,501 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |